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Hemorheological Approach for Early Detection of Chronic Kidney Disease and Diabetic Nephropathy in Type 2 Diabetes

DC FieldValueLanguage
dc.contributor.author강신애-
dc.contributor.author김경래-
dc.contributor.author남지선-
dc.contributor.author박종숙-
dc.contributor.author안철우-
dc.date.accessioned2016-02-04T11:53:35Z-
dc.date.available2016-02-04T11:53:35Z-
dc.date.issued2015-
dc.identifier.issn1520-9156-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141433-
dc.description.abstractBACKGROUND: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of microvascular complications in diabetes. We measured various hemorheologic parameters in type 2 diabetes patients at different stages of chronic kidney disease (CKD) and assessed their possible role as early markers of diabetic nephropathy and renal insufficiency. SUBJECTS AND METHODS: One hundred-five patients with type 2 diabetes were divided into four groups according to glomerular filtration rate (GFR), which represents the kidney function. Hemorheologic parameters, including erythrocyte deformability, fibrinogen/elongation index (EI), and aggregation index (AI) were measured using a microfluidic hemorheometer, and critical shear stress (CSS) was measured using a microfluidic technique. Various metabolic parameters were assessed from fasting blood samples, and the urine albumin-to-creatinine ratio (ACR) was calculated from first morning voided urine. RESULTS: There were significant differences in red blood cell (RBC) deformability, AI, CSS, fibrinogen/EI, and ACR among patients in different stages of CKD (all P<0.05). RBC deformability and fibrinogen/EI significantly differed between normal (GFR >90 mL/min/1.73 m(2)) and CKD stage 2 (GFR 60-90 mL/min/1.73 m(2)) patients, whereas there was no such difference in ACR. In multiple regression analysis, fibrinogen/EI under a moderate shear stress of 3 Pa was an independent predictor of GFR (β=-0.328, P<0.05). Also, AI, CSS, and fibrinogen/EI were significantly different among patients at different stages of diabetic nephropathy, with a significant difference in fibrinogen/EI between normal and microalbuminuric patients (all P<0.05). CONCLUSIONS: RBC deformability and fibrinogen/EI are sensitive parameters measured via point-of-care testing for detecting erythrocyte alterations in early CKD and nephropathy in patients with type 2 diabetes. Further studies are warranted to verify their use as screening tools for diabetic nephropathy and renal impairment.-
dc.description.statementOfResponsibilityopen-
dc.format.extent808~815-
dc.relation.isPartOfDiabetes Technology & Therapeutics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHemorheological Approach for Early Detection of Chronic Kidney Disease and Diabetic Nephropathy in Type 2 Diabetes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorLee Seohui-
dc.contributor.googleauthorLee Min Young-
dc.contributor.googleauthorNam Ji Sun-
dc.contributor.googleauthorKang Shinae-
dc.contributor.googleauthorPark Jong Suk-
dc.contributor.googleauthorShin Sehyun-
dc.contributor.googleauthorAhn Chul Woo-
dc.contributor.googleauthorKim Kyung Rae-
dc.identifier.doi10.1089/dia.2014.0295-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00052-
dc.contributor.localIdA00294-
dc.contributor.localIdA01268-
dc.contributor.localIdA02270-
dc.contributor.localIdA01660-
dc.relation.journalcodeJ00724-
dc.identifier.urlhttp://online.liebertpub.com/doi/10.1089/dia.2014.0295-
dc.contributor.alternativeNameKang, Shin Ae-
dc.contributor.alternativeNameKim, Kyung Rae-
dc.contributor.alternativeNameNam, Ji Sun-
dc.contributor.alternativeNamePark, Jong Suk-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.affiliatedAuthorKang, Shin Ae-
dc.contributor.affiliatedAuthorKim, Kyung Rae-
dc.contributor.affiliatedAuthorNam, Ji Sun-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorPark, Jong Suk-
dc.rights.accessRightsnot free-
dc.citation.volume17-
dc.citation.number11-
dc.citation.startPage808-
dc.citation.endPage815-
dc.identifier.bibliographicCitationDiabetes Technology & Therapeutics, Vol.17(11) : 808-815, 2015-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)

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