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항생제-스멕타이트 복합물 유도 및 소화기계 약물전달체로의 가능성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송영구 | - |
dc.date.accessioned | 2016-02-04T11:52:27Z | - |
dc.date.available | 2016-02-04T11:52:27Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1225-7281 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141392 | - |
dc.description.abstract | In this study, we aimed to make antibiotic-intercalated smectite composites using amoxicillin and clarithromycin as hygroscopic antibiotics, and gentamicin, tobramycin and netilmicin as non-hygroscopic aminoglucosides, and to check their drug delivery potential in gastric system using preliminary in-situ column release test for clarithromycinsmectite composite. All antibiotics were successfully intercalated into the interlayer of smectite by cation-exchange reaction in the batch experiment. Equilibrium batch test showed that clarithromycin-intercalation followed Langmuir isotherm and the possible maximum amount was calculated as 1.811 mmole/g. Clarithromycin was continuously released by the solutions of pH=2, 3, and 4 and the amount was decreased with pH increase. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 199~204 | - |
dc.relation.isPartOf | Economic and Environmental Geology (자원환경지질) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 항생제-스멕타이트 복합물 유도 및 소화기계 약물전달체로의 가능성 | - |
dc.title.alternative | Development of Antibiotic-intercalated Smectite Composites and Its Drug Delivery Potential in Gastric System | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 송윤구 | - |
dc.contributor.googleauthor | 정동훈 | - |
dc.contributor.googleauthor | 송영구 | - |
dc.contributor.googleauthor | 최우현 | - |
dc.identifier.doi | 10.9719/EEG.2015.48.3.199 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02037 | - |
dc.relation.journalcode | J00757 | - |
dc.subject.keyword | antibiotic-smectite composite | - |
dc.subject.keyword | drug delivery | - |
dc.subject.keyword | smectite | - |
dc.subject.keyword | intercalation | - |
dc.subject.keyword | Clarithromycin | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 48 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 204 | - |
dc.identifier.bibliographicCitation | Economic and Environmental Geology (자원환경지질), Vol.48(3) : 199-204, 2015 | - |
dc.identifier.rimsid | 30616 | - |
dc.type.rims | ART | - |
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