Cited 1 times in
Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 노미령 | - |
dc.contributor.author | 정기양 | - |
dc.date.accessioned | 2016-02-04T11:51:51Z | - |
dc.date.available | 2016-02-04T11:51:51Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0193-1091 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141370 | - |
dc.description.abstract | BACKGROUND: Matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinase (TIMP), and membrane-type 1 matrix metalloproteinase (MT1-MMP) are thought to be involved in the destruction of basement membrane and stromal invasion by cancer cells. OBJECTIVE: The aim of this study was to identify and compare MMP and TIMP expression in internal malignancies and paired cutaneous metastatic lesions. MATERIALS AND METHODS: We compared the expression of MMP-2, MMP-9, MT1-MMP, and TIMP-2 in the internal malignancy and paired cutaneous metastatic lesion using immunohistochemical stains. RESULTS: The cutaneous metastatic lesions expressed significantly more MMP-2, MMP-9, and MT1-MMP and significantly less TIMP-2 than did the paired internal malignancies. In breast cancer, cutaneous metastatic lesions expressed significantly more MMP-9 and significantly less TIMP-2 than did the primary breast cancer lesion. In lung cancer, the cutaneous metastatic lesion expressed significantly more MMP-2 and MT1-MMP than did the primary lesion. In stomach cancer, the cutaneous metastatic lesion expressed significantly less TIMP-2 than did the primary lesion. CONCLUSIONS: Our study demonstrates that cutaneous metastatic lesions have different MMPs and TIMP-2 expression patterns compared with their paired internal malignancies. Also, MMPs and TIMP-2 expression differs according to the type of primary cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 381~388 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF DERMATOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Breast Neoplasms/enzymology* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lung Neoplasms/enzymology* | - |
dc.subject.MESH | Lung Neoplasms/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 14/analysis | - |
dc.subject.MESH | Matrix Metalloproteinase 2/analysis | - |
dc.subject.MESH | Matrix Metalloproteinase 9/analysis | - |
dc.subject.MESH | Matrix Metalloproteinases/analysis* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Skin Neoplasms/enzymology* | - |
dc.subject.MESH | Skin Neoplasms/secondary | - |
dc.subject.MESH | Stomach Neoplasms/enzymology* | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Tissue Inhibitor of Metalloproteinase-2/analysis | - |
dc.subject.MESH | Young Adult | - |
dc.title | Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Kim, Tae Hyung | - |
dc.contributor.googleauthor | Jung, Jin Young | - |
dc.contributor.googleauthor | Roh, Hyo Jin | - |
dc.contributor.googleauthor | Chung, Kee Yang | - |
dc.contributor.googleauthor | Roh, Mi Ryung | - |
dc.identifier.doi | 10.1097/DAD.0000000000000184 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01278 | - |
dc.contributor.localId | A03582 | - |
dc.relation.journalcode | J00078 | - |
dc.identifier.eissn | 1533-0311 | - |
dc.identifier.pmid | 25062266 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000372-201505000-00005&LSLINK=80&D=ovft | - |
dc.subject.keyword | cutaneous metastasis | - |
dc.subject.keyword | internal malignancy | - |
dc.subject.keyword | matrix metalloproteinase | - |
dc.subject.keyword | tissue inhibitor of matrix metalloproteinase | - |
dc.contributor.alternativeName | Roh, Mi Ryung | - |
dc.contributor.alternativeName | Chung, Kee Yang | - |
dc.contributor.affiliatedAuthor | Roh, Mi Ryung | - |
dc.contributor.affiliatedAuthor | Chung, Kee Yang | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 381 | - |
dc.citation.endPage | 388 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF DERMATOPATHOLOGY, Vol.37(5) : 381-388, 2015 | - |
dc.identifier.rimsid | 30604 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.