Cited 246 times in
Whole-genome fingerprint of the DNA methylome during human B cell differentiation
DC Field | Value | Language |
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dc.contributor.author | 이승태 | - |
dc.date.accessioned | 2016-02-04T11:51:03Z | - |
dc.date.available | 2016-02-04T11:51:03Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141342 | - |
dc.description.abstract | We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation program by whole-genome bisulfite sequencing and high-density microarrays. We observed that non-CpG methylation disappeared upon B cell commitment, whereas CpG methylation changed extensively during B cell maturation, showing an accumulative pattern and affecting around 30% of all measured CpG sites. Early differentiation stages mainly displayed enhancer demethylation, which was associated with upregulation of key B cell transcription factors and affected multiple genes involved in B cell biology. Late differentiation stages, in contrast, showed extensive demethylation of heterochromatin and methylation gain at Polycomb-repressed areas, and genes with apparent functional impact in B cells were not affected. This signature, which has previously been linked to aging and cancer, was particularly widespread in mature cells with an extended lifespan. Comparing B cell neoplasms with their normal counterparts, we determined that they frequently acquire methylation changes in regions already undergoing dynamic methylation during normal B cell differentiation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NATURE GENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | B-Lymphocytes/physiology* | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | CpG Islands | - |
dc.subject.MESH | DNA Methylation* | - |
dc.subject.MESH | Epigenesis, Genetic/immunology* | - |
dc.subject.MESH | Gene Expression Regulation, Leukemic | - |
dc.subject.MESH | Genome, Human | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukemia, B-Cell/genetics | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.title | Whole-genome fingerprint of the DNA methylome during human B cell differentiation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Marta Kulis | - |
dc.contributor.googleauthor | Angelika Merkel | - |
dc.contributor.googleauthor | Simon Heath | - |
dc.contributor.googleauthor | Ana C Queirós | - |
dc.contributor.googleauthor | Ronald P Schuyler | - |
dc.contributor.googleauthor | Giancarlo Castellano | - |
dc.contributor.googleauthor | Renée Beekman | - |
dc.contributor.googleauthor | Emanuele Raineri | - |
dc.contributor.googleauthor | Anna Esteve | - |
dc.contributor.googleauthor | Guillem Clot | - |
dc.contributor.googleauthor | Néria Verdaguer-Dot | - |
dc.contributor.googleauthor | Martí Duran-Ferrer | - |
dc.contributor.googleauthor | Nuria Russiñol | - |
dc.contributor.googleauthor | Roser Vilarrasa-Blasi | - |
dc.contributor.googleauthor | Simone Ecker | - |
dc.contributor.googleauthor | Vera Pancaldi | - |
dc.contributor.googleauthor | Daniel Rico | - |
dc.contributor.googleauthor | Lidia Agueda | - |
dc.contributor.googleauthor | Julie Blanc | - |
dc.contributor.googleauthor | David Richardson | - |
dc.contributor.googleauthor | Laura Clarke | - |
dc.contributor.googleauthor | Avik Datta | - |
dc.contributor.googleauthor | Marien Pascual | - |
dc.contributor.googleauthor | Xabier Agirre | - |
dc.contributor.googleauthor | Felipe Prosper | - |
dc.contributor.googleauthor | Diego Alignani | - |
dc.contributor.googleauthor | Bruno Paiva | - |
dc.contributor.googleauthor | Gersende Caron | - |
dc.contributor.googleauthor | Thierry Fest | - |
dc.contributor.googleauthor | Marcus O Muench | - |
dc.contributor.googleauthor | Marina E Fomin | - |
dc.contributor.googleauthor | Seung-Tae Lee | - |
dc.contributor.googleauthor | Joseph L Wiemels | - |
dc.contributor.googleauthor | Alfonso Valencia | - |
dc.contributor.googleauthor | Marta Gut | - |
dc.contributor.googleauthor | Paul Flicek | - |
dc.contributor.googleauthor | Hendrik G Stunnenberg | - |
dc.contributor.googleauthor | Reiner Siebert | - |
dc.contributor.googleauthor | Ralf Küppers | - |
dc.contributor.googleauthor | Ivo G Gut | - |
dc.contributor.googleauthor | Elías Campo | - |
dc.contributor.googleauthor | José I Martín-Subero | - |
dc.identifier.doi | 10.1038/ng.3291 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02930 | - |
dc.relation.journalcode | J02294 | - |
dc.identifier.eissn | 1546-1718 | - |
dc.identifier.pmid | 26053498 | - |
dc.identifier.url | http://www.nature.com/ng/journal/v47/n7/full/ng.3291.html | - |
dc.contributor.alternativeName | Lee, Seung Tae | - |
dc.contributor.affiliatedAuthor | Lee, Seung Tae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 746 | - |
dc.citation.endPage | 756 | - |
dc.identifier.bibliographicCitation | NATURE GENETICS, Vol.47(7) : 746-756, 2015 | - |
dc.identifier.rimsid | 30584 | - |
dc.type.rims | ART | - |
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