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Preventive Effect of Human Acellular Dermal Matrix on Post-thyroidectomy Scars and Adhesions: A Randomized, Double-Blinded, Controlled Trial

 Kim, Do Young  ;  Kang, Sang-Wook  ;  Kim, Dae Suk  ;  Shin, Jung U.  ;  Chung, Woong Youn  ;  Park, Cheong Soo  ;  Lee, Ju Hee  ;  Nam, Kee-Hyun 
 DERMATOLOGIC SURGERY, Vol.41(7) : 812-820, 2015 
Journal Title
Issue Date
Acellular Dermis* ; Adult ; Carcinoma, Papillary/surgery* ; Cicatrix/prevention & control* ; Deglutition Disorders/prevention & control* ; Double-Blind Method ; Female ; Humans ; Lymph Node Excision ; Male ; Middle Aged ; Postoperative Complications/prevention & control* ; Skin, Artificial* ; Thyroid Neoplasms/surgery* ; Thyroidectomy* ; Tissue Adhesions/prevention & control* ; Treatment Outcome
BACKGROUND: Acellular dermal matrix (ADM) has been used for antiadhesion formation along with wound healing in various surgical fields. OBJECTIVE: The aim is to assess the efficacy of ADM implantation in the prevention of postoperative scars and adhesions after conventional, open, total thyroidectomy. MATERIALS AND METHODS: Forty-four patients with papillary thyroid carcinoma undergoing thyroidectomy were randomly assigned to the study (ADM implantation) or control group (without ADM). Global photographic assessment, Vancouver scar scale (VSS), objective scar assessment, and swallowing impairment index were assessed at baseline, immediately after surgery, and at 1 and 2 months after surgery. RESULTS: Nineteen control and 20 study group participants completed the study. The mean VSS score of the study group was significantly lower than the controls at both 1 month (3.06 ± 1.25 vs 4.41 ± 1.54, respectively) and 2 months (2.76 ± 1.56 vs 4.35 ± 1.58, respectively) after surgery. Scar quality measures (mean melanin and erythema indexes) were significantly lower in the study group compared with controls. Study group participants had significantly lower swallowing impairment scores than controls. The mean postoperative hospitalization of both groups was not significantly different. CONCLUSION: Acellular dermal matrix-assisted implants appear to improve post-thyroidectomy scar and swallowing impairments without delays in operation time.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Kim, Dae Suk(김대석)
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Park, Cheong Soo(박정수)
Shin, Jung U(신정우) ORCID logo https://orcid.org/0000-0001-5259-6879
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Chung, Woung Youn(정웅윤)
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