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Clinical Impact of Intravascular Ultrasound-Guided Chronic Total Occlusion Intervention With Zotarolimus-Eluting Versus Biolimus-Eluting Stent Implantation: Randomized Study

DC FieldValueLanguage
dc.contributor.author김병극-
dc.contributor.author김중선-
dc.contributor.author신동호-
dc.contributor.author장양수-
dc.contributor.author홍명기-
dc.contributor.author홍범기-
dc.date.accessioned2016-02-04T11:50:02Z-
dc.date.available2016-02-04T11:50:02Z-
dc.date.issued2015-
dc.identifier.issn1941-7640-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141305-
dc.description.abstractBACKGROUND: There have been no randomized studies comparing intravascular ultrasound (IVUS)-guided versus conventional angiography-guided chronic total occlusion (CTO) intervention using new-generation drug-eluting stent Therefore, we conducted a prospective, randomized, multicenter trial designed to test the hypothesis that IVUS-guided CTO intervention is superior to angiography-guided intervention. METHODS AND RESULTS: After successful guidewire crossing, 402 patients with CTOs were randomized to the IVUS-guided group (n=201) or the angiography-guided group (n=201) and secondarily randomized to Resolute zotarolimus-eluting stents or Nobori biolimus-eluting stents. The primary and secondary end points were cardiac death and a major adverse cardiac event defined as the composite of cardiac death, myocardial infarction, or target-vessel revascularization, respectively. After 12-month follow-up, the rate of cardiac death was not significantly different between the IVUS-guided group (0%) and the angiography-guided group (1.0%; P by log-rank test=0.16). However, major adverse cardiac event rates were significantly lower in the IVUS-guided group than that in the angiography-guided group (2.6% versus 7.1%; P=0.035; hazard ratio, 0.35; 95% confidence interval, 0.13-0.97). Occurrence of the composite of cardiac death or myocardial infarction was significantly lower in the IVUS-guided group (0%) than in the angiography-guided group (2.0%; P=0.045). The rates of target-vessel revascularization were not significantly different between the 2 groups. In the comparison between Resolute zotarolimus-eluting stent and Nobori biolimus-eluting stent, major adverse cardiac event rates were not significantly different (4.0% versus 5.7%; P=0.45). CONCLUSIONS: Although IVUS-guided CTO intervention did not significantly reduce cardiac mortality, this randomized study demonstrated that IVUS-guided CTO intervention might improve 12-month major adverse cardiac event rate after new-generation drug-eluting stent implantation when compared with conventional angiography-guided CTO intervention.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCIRCULATION-CARDIOVASCULAR INTERVENTIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAnti-Bacterial Agents/administration & dosage*-
dc.subject.MESHCoronary Angiography/methods-
dc.subject.MESHCoronary Occlusion/mortality-
dc.subject.MESHCoronary Occlusion/therapy*-
dc.subject.MESHDrug-Eluting Stents*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardial Infarction/mortality-
dc.subject.MESHMyocardial Infarction/therapy-
dc.subject.MESHPercutaneous Coronary Intervention/methods*-
dc.subject.MESHProspective Studies-
dc.subject.MESHRandom Allocation-
dc.subject.MESHSirolimus/administration & dosage-
dc.subject.MESHSirolimus/analogs & derivatives*-
dc.subject.MESHUltrasonography, Interventional/methods*-
dc.titleClinical Impact of Intravascular Ultrasound-Guided Chronic Total Occlusion Intervention With Zotarolimus-Eluting Versus Biolimus-Eluting Stent Implantation: Randomized Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorDong-Ho Shin-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.contributor.googleauthorHun Sik Park-
dc.contributor.googleauthorSeung-Woon Rha-
dc.contributor.googleauthorGary S. Mintz-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorJe Sang Kim-
dc.contributor.googleauthorSeung-Jin Lee-
dc.contributor.googleauthorHee-Yeol Kim-
dc.contributor.googleauthorBum-Kee Hong-
dc.contributor.googleauthorWoong-Chol Kang-
dc.contributor.googleauthorJin-Ho Choi-
dc.contributor.googleauthorYangsoo Jang-
dc.identifier.doi10.1161/CIRCINTERVENTIONS.115.002592-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA02097-
dc.contributor.localIdA03448-
dc.contributor.localIdA04391-
dc.contributor.localIdA04394-
dc.relation.journalcodeJ00539-
dc.identifier.eissn1941-7632-
dc.identifier.pmid26156151-
dc.identifier.urlhttp://circinterventions.ahajournals.org/content/8/7/e002592.long-
dc.subject.keywordcoronary occlusion-
dc.subject.keyworddrug-eluting stents-
dc.subject.keywordultrasonography , interventional-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.alternativeNameHong, Bum Kee-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorHong, Bum Kee-
dc.rights.accessRightsnot free-
dc.citation.volume8-
dc.citation.number7-
dc.citation.startPage002592-
dc.identifier.bibliographicCitationCIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol.8(7) : 002592, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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