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DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance

DC FieldValueLanguage
dc.contributor.author박채규-
dc.date.accessioned2016-02-04T11:48:46Z-
dc.date.available2016-02-04T11:48:46Z-
dc.date.issued2015-
dc.identifier.issn1074-7613-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141259-
dc.description.abstractTissue effector cells of the monocyte lineage can differentiate into different cell types with specific cell function depending on their environment. The phenotype, developmental requirements, and functional mechanisms of immune protective macrophages that mediate the induction of transplantation tolerance remain elusive. Here, we demonstrate that costimulatory blockade favored accumulation of DC-SIGN-expressing macrophages that inhibited CD8(+) T cell immunity and promoted CD4(+)Foxp3(+) Treg cell expansion in numbers. Mechanistically, that simultaneous DC-SIGN engagement by fucosylated ligands and TLR4 signaling was required for production of immunoregulatory IL-10 associated with prolonged allograft survival. Deletion of DC-SIGN-expressing macrophages in vivo, interfering with their CSF1-dependent development, or preventing the DC-SIGN signaling pathway abrogated tolerance. Together, the results provide new insights into the tolerogenic effects of costimulatory blockade and identify DC-SIGN(+) suppressive macrophages as crucial mediators of immunological tolerance with the concomitant therapeutic implications in the clinic.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1143~1158-
dc.relation.isPartOfImmunity-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCD8-Positive T-Lymphocytes/immunology-
dc.subject.MESHCell Adhesion Molecules/genetics-
dc.subject.MESHCell Adhesion Molecules/metabolism*-
dc.subject.MESHCells, Cultured-
dc.subject.MESHForkhead Transcription Factors/metabolism-
dc.subject.MESHGraft Rejection/etiology-
dc.subject.MESHGraft Rejection/prevention & control*-
dc.subject.MESHHeart Transplantation*-
dc.subject.MESHImmune Tolerance-
dc.subject.MESHInterleukin-10/metabolism-
dc.subject.MESHLectins, C-Type/genetics-
dc.subject.MESHLectins, C-Type/metabolism*-
dc.subject.MESHMacrophage Colony-Stimulating Factor/metabolism-
dc.subject.MESHMacrophages/immunology*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMolecular Targeted Therapy-
dc.subject.MESHReceptors, Cell Surface/genetics-
dc.subject.MESHReceptors, Cell Surface/metabolism*-
dc.subject.MESHSignal Transduction-
dc.subject.MESHT-Lymphocytes, Regulatory/immunology*-
dc.subject.MESHToll-Like Receptor 4/metabolism-
dc.subject.MESHTransplantation Tolerance-
dc.subject.MESHUp-Regulation-
dc.titleDC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorPatricia Conde-
dc.contributor.googleauthorMercedes Rodriguez-
dc.contributor.googleauthorWilliam van der Touw-
dc.contributor.googleauthorAna Jimenez-
dc.contributor.googleauthorMatthew Burns-
dc.contributor.googleauthorJennifer Miller-
dc.contributor.googleauthorManisha Brahmachary-
dc.contributor.googleauthorHui-ming Chen-
dc.contributor.googleauthorPeter Boros-
dc.contributor.googleauthorFrancisco Rausell-Palamos-
dc.contributor.googleauthorTae Jin Yun-
dc.contributor.googleauthorPaloma Riquelme-
dc.contributor.googleauthorAlberto Rastrojo-
dc.contributor.googleauthorBegoña Aguado-
dc.contributor.googleauthorJoan Stein-Streilein-
dc.contributor.googleauthorMasato Tanaka-
dc.contributor.googleauthorLan Zhou-
dc.contributor.googleauthorJunfeng Zhang-
dc.contributor.googleauthorTodd L. Lowary-
dc.contributor.googleauthorFlorent Ginhoux-
dc.contributor.googleauthorChae Gyu Park-
dc.contributor.googleauthorCheolho Cheong-
dc.contributor.googleauthorJoshua Brody-
dc.contributor.googleauthorShannon J. Turley-
dc.contributor.googleauthorSergio A. Lira-
dc.contributor.googleauthorVincenzo Bronte-
dc.contributor.googleauthorSiamon Gordon-
dc.contributor.googleauthorPeter S. Heeger-
dc.contributor.googleauthorMiriam Merad-
dc.contributor.googleauthorJames Hutchinson-
dc.identifier.doi10.1016/j.immuni.2015.05.009-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01718-
dc.relation.journalcodeJ01034-
dc.identifier.pmid26070485-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S107476131500206X-
dc.contributor.alternativeNamePark, Chae Gyu-
dc.contributor.affiliatedAuthorPark, Chae Gyu-
dc.rights.accessRightsnot free-
dc.citation.volume42-
dc.citation.number6-
dc.citation.startPage1143-
dc.citation.endPage1158-
dc.identifier.bibliographicCitationImmunity, Vol.42(6) : 1143-1158, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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