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The C-Reactive Protein/Albumin Ratio as an Independent Predictor of Mortality in Patients with Severe Sepsis or Septic Shock Treated with Early Goal-Directed Therapy

DC FieldValueLanguage
dc.contributor.author안혜원-
dc.contributor.author최흔-
dc.contributor.author한상훈-
dc.contributor.author전용덕-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author구남수-
dc.contributor.author김민형-
dc.contributor.author김선빈-
dc.contributor.author김영삼-
dc.contributor.author김재경-
dc.contributor.author김정호-
dc.contributor.author김준명-
dc.contributor.author송영구-
dc.contributor.author송제은-
dc.contributor.author안진영-
dc.date.accessioned2016-02-04T11:47:16Z-
dc.date.available2016-02-04T11:47:16Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141202-
dc.description.abstractBACKGROUND: Sepsis, including severe sepsis and septic shock, is a major cause of morbidity and mortality. Albumin and C-reactive protein (CRP) are considered as good diagnostic markers for sepsis. Thus, initial CRP and albumin levels were combined to ascertain their value as an independent predictor of 180-day mortality in patients with severe sepsis and septic shock. MATERIALS AND METHODS: We conducted a retrospective cohort study involving 670 patients (>18 years old) who were admitted to the emergency department and who had received a standardized resuscitation algorithm (early goal-directed therapy) for severe sepsis and septic shock, from November 2007 to February 2013, at a tertiary hospital in Seoul, Korea. The outcome measured was 180-day all-cause mortality. A multivariate Cox proportional hazard model was used to identify the independent risk factors for mortality. A receiver operating characteristic (ROC) curve analysis was conducted to compare the predictive accuracy of the CRP/albumin ratio at admission. RESULTS: The 180-day mortality was 28.35% (190/670). Based on the multivariate Cox proportional hazard analysis, age, the CRP/albumin ratio at admission (adjusted HR 1.06, 95% CI 1.03-1.10, p<0.001), lactate level at admission (adjusted HR 1.10, 95% CI 1.05-1.14, p<0.001), and the Sequential Organ Failure Assessment (SOFA) score at admission (adjusted HR 1.12, 95% CI 1.07-1.18, p<0.001) were independent predictors of 180-day mortality. The area under the curve of CRP alone and the CRP/albumin ratio at admission for 180-day mortality were 0.5620 (P<0.001) and 0.6211 (P<0.001), respectively. CONCLUSION: The CRP/albumin ratio was an independent predictor of mortality in patients with severe sepsis or septic shock.-
dc.description.statementOfResponsibilityopen-
dc.format.extente0132109-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHArea Under Curve-
dc.subject.MESHC-Reactive Protein/analysis*-
dc.subject.MESHCohort Studies-
dc.subject.MESHEmergency Service, Hospital-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLactic Acid/analysis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHROC Curve-
dc.subject.MESHResuscitation-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSerum Albumin/analysis-
dc.subject.MESHShock, Septic/mortality-
dc.subject.MESHShock, Septic/therapy*-
dc.titleThe C-Reactive Protein/Albumin Ratio as an Independent Predictor of Mortality in Patients with Severe Sepsis or Septic Shock Treated with Early Goal-Directed Therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMin Hyung Kim-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorJe Eun Song-
dc.contributor.googleauthorHeun Choi-
dc.contributor.googleauthorHea Won Ann-
dc.contributor.googleauthorJae Kyoung Kim-
dc.contributor.googleauthorJung Ho Kim-
dc.contributor.googleauthorYong Duk Jeon-
dc.contributor.googleauthorSun Bean Kim-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorJun Young Choi-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1371/journal.pone.0132109-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02275-
dc.contributor.localIdA04227-
dc.contributor.localIdA04286-
dc.contributor.localIdA03534-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA00189-
dc.contributor.localIdA00480-
dc.contributor.localIdA00547-
dc.contributor.localIdA00707-
dc.contributor.localIdA00856-
dc.contributor.localIdA00902-
dc.contributor.localIdA00953-
dc.contributor.localIdA02037-
dc.contributor.localIdA02059-
dc.contributor.localIdA02267-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid26158725-
dc.contributor.alternativeNameAnn, Hea Won-
dc.contributor.alternativeNameChoi, Heun-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameJeon, Yong Duk-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, Min Hyung-
dc.contributor.alternativeNameKim, Sun Bean-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameKim, Jae Kyoung-
dc.contributor.alternativeNameKim, Jung Ho-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameSong, Je Eun-
dc.contributor.alternativeNameAhn, Jin Young-
dc.contributor.affiliatedAuthorAnn, Hea Won-
dc.contributor.affiliatedAuthorChoi, Heun-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorJeon, Yong Duk-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, Min Hyung-
dc.contributor.affiliatedAuthorKim, Sun Bean-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorKim, Jae Kyoung-
dc.contributor.affiliatedAuthorKim, Jung Ho-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorSong, Je Eun-
dc.contributor.affiliatedAuthorAhn, Jin Young-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.number7-
dc.citation.startPagee0132109-
dc.identifier.bibliographicCitationPLOS ONE, Vol.10(7) : e0132109, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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