Cited 11 times in
A Randomized, Double-blind, Non-inferiority Trial of Magnesium Sulphate versus Dexamethasone for Prevention of Postoperative Sore Throat after Lumbar Spinal Surgery in the Prone Position
DC Field | Value | Language |
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dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 박진하 | - |
dc.contributor.author | 장재원 | - |
dc.date.accessioned | 2016-02-04T11:47:09Z | - |
dc.date.available | 2016-02-04T11:47:09Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141198 | - |
dc.description.abstract | BACKGROUND: Postoperative sore throat (POST) is a frequent complication of tracheal intubation, particularly after surgery in the prone position. We designed this study to validate the non-inferiority of magnesium sulphate against dexamethasone for prevention of POST after lumbar spinal surgery. METHODS: One hundred and forty-six patients were randomly allocated to receive either magnesium or dexamethasone. Before anesthetic induction, the magnesium group (n = 73) received magnesium sulphate 30 mg/kg followed by 10 mg/kg/h by continuous infusion until the end of surgery. The dexamethasone group (n = 73) received dexamethasone 8 mg. The primary endpoint was the overall incidence of POST, which was assessed serially over 48 hr postoperatively. The predefined margin of non-inferiority for magnesium against dexamethasone was 15%. RESULTS: Overall incidences of POST at rest (50.7% versus 49.3% in the magnesium and dexamethasone group, respectively, p = 0.869) and swallowing (65.8% versus 61.6% in the magnesium and dexamethasone group, respectively, p = 0.606) were not different between the groups. The upper limit of the 90% confidence interval, which must be lower than the predefined margin of non-inferiority to prove the non-inferiority of magnesium sulphate against dexamethasone, for at rest and swallowing were 14.97% (p = 0.0496) and 17.19% (p = 0.0854), respectively. The incidences and severities of POST and hoarseness were also not different between the groups throughout the study period. CONCLUSIONS: Prophylactic magnesium sulphate appears to be non-inferior to dexamethasone for the prevention of POST at rest in patients undergoing lumbar spinal surgery in the prone position. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Dexamethasone/therapeutic use* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lumbar Vertebrae/surgery* | - |
dc.subject.MESH | Magnesium Sulfate/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pharyngitis/epidemiology | - |
dc.subject.MESH | Pharyngitis/prevention & control* | - |
dc.subject.MESH | Postoperative Complications/epidemiology | - |
dc.subject.MESH | Postoperative Complications/prevention & control* | - |
dc.subject.MESH | Prone Position | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | A Randomized, Double-blind, Non-inferiority Trial of Magnesium Sulphate versus Dexamethasone for Prevention of Postoperative Sore Throat after Lumbar Spinal Surgery in the Prone Position | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Jin Ha Park | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Jong-Wook Song | - |
dc.contributor.googleauthor | Jaewon Jang | - |
dc.contributor.googleauthor | Ji Hoon Kim | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.7150/ijms.12831 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A01704 | - |
dc.relation.journalcode | J02917 | - |
dc.identifier.eissn | 1449-1907 | - |
dc.identifier.pmid | 26516308 | - |
dc.subject.keyword | Dexamethasone | - |
dc.subject.keyword | Magnesium | - |
dc.subject.keyword | Postoperative sore throat | - |
dc.subject.keyword | Prone position | - |
dc.contributor.alternativeName | Song, Jong Wook | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Park, Jin Ha | - |
dc.contributor.affiliatedAuthor | Song, Jong Wook | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Park, Jin Ha | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 797 | - |
dc.citation.endPage | 804 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, Vol.12(10) : 797-804, 2015 | - |
dc.identifier.rimsid | 29361 | - |
dc.type.rims | ART | - |
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