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Current Issues and Clinical Evidence in Tumor-Infiltrating Lymphocytes in Breast Cancer

Authors
 Sung Gwe Ahn ; Joon Jeong ; Woo Hee Jung ; SoonWon Hong 
Citation
 Journal of Pathology and Translational Medicine, Vol.49(5) : 355~363, 2015 
Journal Title
 Journal of Pathology and Translational Medicine 
ISSN
 2383-7837 
Issue Date
2015
Abstract
With the advance in personalized therapeutic strategies in patients with breast cancer, there is an increasing need for biomarker-guided therapy. Although the immunogenicity of breast cancer has not been strongly considered in research or practice, tumor-infiltrating lymphocytes (TILs) are emerging as biomarkers mediating tumor response to treatments. Earlier studies have provided evidence that the level of TILs has prognostic value and the potential for predictive value, particularly in triple-negative and human epidermal growth factor receptor 2–positive breast cancer. Moreover, the level of TILs has been associated with treatment outcome in patients undergoing neoadjuvant chemotherapy. To date, no standardized methodology for measuring TILs has been established. In this article, we review current issues and clinical evidence for the use of TILs in breast cancer.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141184
DOI
10.4132/jptm.2015.07.29
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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