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Exovascular application of epigallocatechin-3-O-gallate-releasing electrospun poly(L-lactide glycolic acid) fiber sheets to reduce intimal hyperplasia in injured abdominal aorta

Authors
 Mi Hee Lee  ;  Byeong-ju Kwon  ;  Min-Ah Koo  ;  Eui Hwa Jang  ;  Gyeung Mi Seon  ;  Jong-Chul Park 
Citation
 BIOMEDICAL MATERIALS, Vol.10(5) : 055010, 2015 
Journal Title
 BIOMEDICAL MATERIALS 
ISSN
 1748-6041 
Issue Date
2015
Keywords
epigallocatechin-3-O-gallate ; local drug delivery ; electrospun poly(l-lactide glycolic acid) fiber sheets ; intimal hyperplasia ; balloon injury
Abstract
Intimal hyperplasia is an excessive ingrowth of tissue resulting in chronic structural lesions commonly found at sites of atherosclerotic lesions, arterial angioplasty, vascular graft anastomoses, and other vascular abnormalities. Epigallocatechin-3-O-gallate (EGCG) was shown to elicit antioxidant, anti-proliferative, and anti-thrombogenic effects. In this study, we used an electrospinning technique to synthesize EGCG-eluting biodegradable poly(L-lactide glycolic acid) (PLGA) fiber sheets for local delivery of EGCG and investigated the effect of their exovascular application on intimal hyperplasia following balloon-induced abdominal aorta injury in a rabbit experimental model. The morphology of the composite sheets was characterized using scanning electron microscopy and Fourier transform-infrared spectroscopy. EGCG was loaded and dispersed into the PLGA-based electrospun fibers. The EGCG-loaded PLGA sheets exhibited sustained EGCG release following the initial 24 h of burst release in phosphate-buffered saline. In vivo studies demonstrated significant inhibition of intimal hyperplasia following the application of the EGCG-eluting electrospun PLGA fiber sheets, compared with vehicle PLGA controls. In conclusion, our results show that exovascular application of EGCG-eluting PLGA electrospun fiber sheets may provide a useful system for the effective local delivery of drugs for the prevention of intimal hyperplasia.
Full Text
http://stacks.iop.org/1748-6041/10/055010
DOI
10.1088/1748-6041/10/5/055010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Koo, Min-Ah(구민아) ORCID logo https://orcid.org/0000-0002-8671-1131
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Seon, Gyeung Mi(선경미) ORCID logo https://orcid.org/0000-0002-0766-1106
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141183
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