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Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia

 Hyun Seok Choi  ;  Sung Soo Ahn  ;  Na Young Shin  ;  Jinna Kim  ;  Jae Hyung Kim  ;  Jong Eun Lee  ;  Hye Yeon Lee  ;  Ji Hoe Heo  ;  Seung Koo Lee 
 Korean Journal of Radiology, Vol.16(4) : 791-797, 2015 
Journal Title
 Korean Journal of Radiology 
Issue Date
OBJECTIVE: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. MATERIALS AND METHODS: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (K(trans), ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue. RESULTS: All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001). CONCLUSION: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and K(trans) shows the strongest correlation among the tested parameters.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
김진아(Kim, Jinna) ORCID logo https://orcid.org/0000-0002-9978-4356
신나영(Shin, Na Young)
안성수(Ahn, Sung Soo) ORCID logo https://orcid.org/0000-0002-0503-5558
이승구(Lee, Seung Koo) ORCID logo https://orcid.org/0000-0001-5646-4072
이종은(Lee, Jong Eun) ORCID logo https://orcid.org/0000-0001-6203-7413
이혜연(Lee, Hye Yeon) ORCID logo https://orcid.org/0000-0001-6945-1967
허지회(Heo, Ji Hoe) ORCID logo https://orcid.org/0000-0001-9898-3321
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