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Cited 4 times in

Lack of ROS1 Gene Rearrangement in Glioblastoma Multiforme

DC FieldValueLanguage
dc.contributor.author조병철-
dc.contributor.author김세훈-
dc.contributor.author임선민-
dc.contributor.author장종희-
dc.date.accessioned2016-02-04T11:45:40Z-
dc.date.available2016-02-04T11:45:40Z-
dc.date.issued2015-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141141-
dc.description.abstractGlioblastoma multiforme (GBM) is the most aggressive type of brain tumor, and the prognosis remains poor. Rearrangement of ROS1 gene, which was shown to have an oncogenic potential, was previously discovered in GBM cell lines. In this pilot study, we aimed to identify the incidence of ROS1 rearrangement in GBM patient tissues to explore novel biomarkers for therapeutic strategy. Formalin-fixed and paraffin-embedded (FFPE) tissue sections from 109 patients with GBM were screened for ROS1 rearrangement by anti-ROS immunohistochemistry (IHC) and ROS1 break-apart fluorescent in situ hybridization (FISH) assays. O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation and Isocitrate dehydrogenase 1 (IDH1) mutation status were also assessed. All samples were interpreted by two experienced pathologists who were blinded to the clinical data. A total of 109 samples were collected and all samples were examined for ROS1 rearrangement by IHC and FISH assays, and none was found to harbor ROS1 rearrangement. MGMT gene methylation was found in 42 (39.2%) cases, and IDH1 mutation was found in 6 (5.5%) cases. In this study, ROS1 rearrangement was not identified in GBM patients, and thus it is difficult to classify ROS1 rearrangement as a novel molecular subset in GBM patients for now.-
dc.description.statementOfResponsibilityopen-
dc.format.extente0137678-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHDNA Methylation-
dc.subject.MESHDNA Modification Methylases/genetics-
dc.subject.MESHDNA Repair Enzymes/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGene Rearrangement*-
dc.subject.MESHGlioblastoma/diagnosis-
dc.subject.MESHGlioblastoma/genetics*-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHIn Situ Hybridization, Fluorescence-
dc.subject.MESHIsocitrate Dehydrogenase/genetics-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPilot Projects-
dc.subject.MESHPrognosis-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHProtein-Tyrosine Kinases/genetics*-
dc.subject.MESHProto-Oncogene Proteins/genetics*-
dc.subject.MESHTumor Suppressor Proteins/genetics-
dc.titleLack of ROS1 Gene Rearrangement in Glioblastoma Multiforme-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorSun Min Lim-
dc.contributor.googleauthorJunjeong Choi-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorJinyoung Sohn-
dc.contributor.googleauthorKristine Jacobson-
dc.contributor.googleauthorFrank Policht-
dc.contributor.googleauthorJohn Schulz-
dc.contributor.googleauthorByoung Chul Cho-
dc.contributor.googleauthorSe Hoon Kim-
dc.identifier.doi10.1371/journal.pone.0137678-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03369-
dc.contributor.localIdA03470-
dc.contributor.localIdA03822-
dc.contributor.localIdA00610-
dc.relation.journalcodeJ02540-
dc.identifier.pmid26366867-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameLim, Sun Min-
dc.contributor.alternativeNameChang, Jong Hee-
dc.contributor.affiliatedAuthorLim, Sun Min-
dc.contributor.affiliatedAuthorChang, Jong Hee-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.number9-
dc.citation.startPagee0137678-
dc.identifier.bibliographicCitationPLoS One, Vol.10(9) : e0137678, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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