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Incidence, clinical presentation, and predictors of early neoatherosclerosis after drug-eluting stent implantation

DC FieldValueLanguage
dc.contributor.author김병극-
dc.contributor.author김중선-
dc.contributor.author김충기-
dc.contributor.author신동호-
dc.contributor.author이승률-
dc.contributor.author장양수-
dc.contributor.author최동훈-
dc.contributor.author홍명기-
dc.contributor.author고영국-
dc.contributor.author이승율-
dc.date.accessioned2016-02-04T11:45:18Z-
dc.date.available2016-02-04T11:45:18Z-
dc.date.issued2015-
dc.identifier.issn0002-8703-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141127-
dc.description.abstractBACKGROUND: Compared with bare-metal stents, neoatherosclerosis reportedly develops earlier and more frequently after drug-eluting stent (DES) implantation. This study evaluated the incidence, clinical presentation, and predictors of early neoatherosclerosis after DES implantation. METHODS: Neointimal characteristics were evaluated in 449 patients (482 lesions) who underwent follow-up optical coherence tomography ≤12 months after DES implantation (median 9.1 months) and displayed a mean neointimal thickness >100 μm. Neoatherosclerosis was defined as neointima with the presence of lipid or calcification. RESULTS: Early neoatherosclerosis, defined as occurrence of neoatherosclerosis within 12 months after DES implantation, was observed in 31 lesions (6.4%). Compared with patients without early neoatherosclerosis, those with early neoatherosclerosis presented with a higher incidence of clinical symptoms (13% vs 57%, respectively; P < .001) and had undergone a higher frequency of target-lesion revascularization (9% vs 55%, respectively; P < .001) at the time of optical coherence tomography follow-up. Multivariate logistic regression analysis showed that independent predictors of early neoatherosclerosis were hypertension (odds ratio 3.20, 95% CI 1.32-7.78, P = .010) and pre-stent low-density lipoprotein cholesterol ≥130 mg/dL at the time of the index procedure (odds ratio 3.89, 95% CI, 1.62-9.36, P = .002). CONCLUSIONS: Early neoatherosclerosis was detected in 6.4% of DES-treated lesions with neointimal thickness >100 μm at a median of 9.1 months after DES implantation. The occurrence of early neoatherosclerosis was significantly associated with presentation of clinical symptoms. Independent predictors of early neoatherosclerosis were hypertension and high pre-stent low-density lipoprotein cholesterol at the time of the index procedure.-
dc.description.statementOfResponsibilityopen-
dc.format.extent591~597-
dc.relation.isPartOfAMERICAN HEART JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHArteriosclerosis/diagnosis-
dc.subject.MESHArteriosclerosis/epidemiology*-
dc.subject.MESHArteriosclerosis/etiology-
dc.subject.MESHCoronary Artery Disease/surgery*-
dc.subject.MESHCoronary Vessels/pathology*-
dc.subject.MESHDrug-Eluting Stents/adverse effects*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeointima/pathology*-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPercutaneous Coronary Intervention/adverse effects*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.subject.MESHTomography, Optical Coherence/methods-
dc.titleIncidence, clinical presentation, and predictors of early neoatherosclerosis after drug-eluting stent implantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorChoongki Kim-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorSeung-Yul Lee-
dc.contributor.googleauthorDong-Ho Shin-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.identifier.doi10.1016/j.ahj.2015.06.005-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA01061-
dc.contributor.localIdA02097-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.contributor.localIdA04391-
dc.contributor.localIdA00127-
dc.contributor.localIdA02922-
dc.relation.journalcodeJ00069-
dc.identifier.eissn1097-6744-
dc.identifier.pmid26385044-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0002870315003750-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameKim, Choong Ki-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameLee, Seung Yul-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorKim, Choong Ki-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorLee, Seung Yul-
dc.rights.accessRightsnot free-
dc.citation.volume170-
dc.citation.number3-
dc.citation.startPage591-
dc.citation.endPage597-
dc.identifier.bibliographicCitationAMERICAN HEART JOURNAL, Vol.170(3) : 591-597, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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