Cited 14 times in
Cystatin C as a predictive marker of renal dysfunction and mid-term outcomes following off-pump coronary artery bypass grafting
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승현 | - |
dc.contributor.author | 주현철 | - |
dc.contributor.author | 유경종 | - |
dc.contributor.author | 윤영남 | - |
dc.contributor.author | 이삭 | - |
dc.date.accessioned | 2016-02-04T11:44:46Z | - |
dc.date.available | 2016-02-04T11:44:46Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1355-6037 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141106 | - |
dc.description.abstract | OBJECTIVE: To determine whether plasma cystatin C and creatinine levels after isolated off-pump coronary artery bypass grafting (OPCAB) are predictive of postoperative renal dysfunction and clinical outcomes. METHODS: Between January 2008 and December 2013, 1033 who underwent isolated OPCAB were recruited. The patients were divided into three groups according to the preoperative level of cystatin C: low (0.83 mg/L>), mid (0.83-1.13 mg/L) and high (1.13 mg/L<). The endpoints of all-cause mortality and major adverse cerebrovascular and cardiovascular events were compared among three groups using the Kaplan-Meier method. The predictive power of cystatin C was compared with creatinine using receiver operating curves. RESULTS: Follow-up was complete in all of the included patients at a mean of 2.9±1.5 years. Within the follow-up period, 9 early (30-day mortality) and 46 late deaths occurred. The 30-day mortality was zero, four (44%), and five (56%) cases in low, mid and high groups, respectively (p=0.03). The cut-off value of cystatin C for renal dysfunction prediction was approximately 1.04 (mg/L, p<0.001), and cystatin C showed greater predictive power than creatinine for renal dysfunction (area under the curve=0.73 vs 0.65; p=0.01). One-year and five-year overall survival in low, mid and high groups were 99.2%, 98.9% and 94.3%, and 97.9%, 97.3% and 86.3%, respectively (low vs high, p=0.01). CONCLUSIONS: Cystatin C is a stronger predictor of postoperative renal dysfunction than serum creatinine, and its level is directly correlated with mid-term OPCAB adverse results. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1562~1568 | - |
dc.relation.isPartOf | HEART | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenal Cortex Hormones/therapeutic use | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Azathioprine/therapeutic use | - |
dc.subject.MESH | Colectomy/statistics & numerical data | - |
dc.subject.MESH | Colitis, Ulcerative/drug therapy* | - |
dc.subject.MESH | Cyclosporine/therapeutic use* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use* | - |
dc.subject.MESH | Infliximab/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies Aged | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Coronary Artery Bypass, Off-Pump/adverse effects* | - |
dc.subject.MESH | Coronary Artery Bypass, Off-Pump/mortality | - |
dc.subject.MESH | Creatinine/blood | - |
dc.subject.MESH | Cystatin C/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Kidney/physiopathology | - |
dc.subject.MESH | Kidney Diseases/blood | - |
dc.subject.MESH | Kidney Diseases/diagnosis | - |
dc.subject.MESH | Kidney Diseases/etiology* | - |
dc.subject.MESH | Kidney Diseases/mortality | - |
dc.subject.MESH | Kidney Diseases/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Cystatin C as a predictive marker of renal dysfunction and mid-term outcomes following off-pump coronary artery bypass grafting | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Seung Hyun Lee | - |
dc.contributor.googleauthor | Young-Nam Youn | - |
dc.contributor.googleauthor | Hyun Chel Choo | - |
dc.contributor.googleauthor | Sak Lee | - |
dc.contributor.googleauthor | Kyung-Jong Yoo | - |
dc.identifier.doi | 10.1136/heartjnl-2015-307986 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02935 | - |
dc.contributor.localId | A03960 | - |
dc.contributor.localId | A02453 | - |
dc.contributor.localId | A02576 | - |
dc.contributor.localId | A02807 | - |
dc.relation.journalcode | J00976 | - |
dc.identifier.eissn | 1468-201X | - |
dc.identifier.pmid | 26215986 | - |
dc.contributor.alternativeName | Lee, Seung Hyun | - |
dc.contributor.alternativeName | Joo, Hyun Chel | - |
dc.contributor.alternativeName | Yoo, Kyung Jong | - |
dc.contributor.alternativeName | Youn, Young Nam | - |
dc.contributor.alternativeName | Lee, Sak | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Joo, Hyun Chel | - |
dc.contributor.affiliatedAuthor | Yoo, Kyung Jong | - |
dc.contributor.affiliatedAuthor | Youn, Young Nam | - |
dc.contributor.affiliatedAuthor | Lee, Sak | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 101 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 1562 | - |
dc.citation.endPage | 1568 | - |
dc.identifier.bibliographicCitation | HEART, Vol.101(19) : 1562-1568, 2015 | - |
dc.identifier.rimsid | 30515 | - |
dc.type.rims | ART | - |
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