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Cited 12 times in

Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study

DC FieldValueLanguage
dc.contributor.author김덕환-
dc.contributor.author김원호-
dc.contributor.author김은혜-
dc.contributor.author김태일-
dc.contributor.author박수정-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.date.accessioned2016-02-04T11:44:44Z-
dc.date.available2016-02-04T11:44:44Z-
dc.date.issued2015-
dc.identifier.issn1976-2283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141105-
dc.description.abstractBACKGROUND/AIMS: In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS: Between January 1995 and May 2012, the medical records of 43 patients with corticosteroid-refractory UC who received either infliximab or cyclosporine as a rescue therapy at a tertiary care hospital in Korea were reviewed. RESULTS: Among the 43 patients, 10 underwent rescue therapy with cyclosporine and the remaining 33 patients received infliximab. A follow-up of 12 months was completed for all patients. The colectomy rate at 12 months was 30% and 3% in the cyclosporine and the infliximab groups, respectively (p=0.034). However, the Cox proportional hazard model indicated that the treatment of rescue therapy was not an independent associate factor for preventing colectomy (p=0.164). In the subgroup analysis, infliximab with azathioprine was superior to cyclosporine for preventing colectomy (hazard ratio of infliximab with azathioprine compared with cyclosporine only, 0.073; 95% confidence interval, 0.008 to 0.629). CONCLUSIONS: No difference between infliximab and cyclosporine with respect to preventing colectomy was noted. However, infliximab with azathioprine may be more effective than cyclosporine alone for preventing colectomy.-
dc.description.statementOfResponsibilityopen-
dc.format.extent601~606-
dc.relation.isPartOfGUT AND LIVER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdrenal Cortex Hormones/therapeutic use-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAzathioprine/therapeutic use-
dc.subject.MESHColectomy/statistics & numerical data-
dc.subject.MESHColitis, Ulcerative/drug therapy*-
dc.subject.MESHCyclosporine/therapeutic use*-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/therapeutic use*-
dc.subject.MESHInfliximab/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSalvage Therapy/methods*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleInfliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorEun Hye Kim-
dc.contributor.googleauthorDuk Hwan Kim-
dc.contributor.googleauthorSoo Jung Park-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi10.5009/gnl14120-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00377-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA04404-
dc.contributor.localIdA04030-
dc.contributor.localIdA00827-
dc.contributor.localIdA01539-
dc.relation.journalcodeJ00954-
dc.identifier.eissn2005-1212-
dc.identifier.pmid25473080-
dc.subject.keywordColitis, ulcerative-
dc.subject.keywordCyclosporine-
dc.subject.keywordInfliximab-
dc.contributor.alternativeNameKim, Duk Hwan-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Eun Hye-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Soo Jung-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Duk Hwan-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.contributor.affiliatedAuthorKim, Eun Hye-
dc.contributor.affiliatedAuthorPark, Soo Jung-
dc.rights.accessRightsfree-
dc.citation.volume9-
dc.citation.number5-
dc.citation.startPage601-
dc.citation.endPage606-
dc.identifier.bibliographicCitationGUT AND LIVER, Vol.9(5) : 601-606, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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