Cited 20 times in
Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김덕환 | - |
dc.contributor.author | 김원호 | - |
dc.contributor.author | 김은혜 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 박수정 | - |
dc.contributor.author | 천재희 | - |
dc.contributor.author | 홍성필 | - |
dc.date.accessioned | 2016-02-04T11:44:44Z | - |
dc.date.available | 2016-02-04T11:44:44Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141105 | - |
dc.description.abstract | BACKGROUND/AIMS: In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS: Between January 1995 and May 2012, the medical records of 43 patients with corticosteroid-refractory UC who received either infliximab or cyclosporine as a rescue therapy at a tertiary care hospital in Korea were reviewed. RESULTS: Among the 43 patients, 10 underwent rescue therapy with cyclosporine and the remaining 33 patients received infliximab. A follow-up of 12 months was completed for all patients. The colectomy rate at 12 months was 30% and 3% in the cyclosporine and the infliximab groups, respectively (p=0.034). However, the Cox proportional hazard model indicated that the treatment of rescue therapy was not an independent associate factor for preventing colectomy (p=0.164). In the subgroup analysis, infliximab with azathioprine was superior to cyclosporine for preventing colectomy (hazard ratio of infliximab with azathioprine compared with cyclosporine only, 0.073; 95% confidence interval, 0.008 to 0.629). CONCLUSIONS: No difference between infliximab and cyclosporine with respect to preventing colectomy was noted. However, infliximab with azathioprine may be more effective than cyclosporine alone for preventing colectomy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 601~606 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenal Cortex Hormones/therapeutic use | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Azathioprine/therapeutic use | - |
dc.subject.MESH | Colectomy/statistics & numerical data | - |
dc.subject.MESH | Colitis, Ulcerative/drug therapy* | - |
dc.subject.MESH | Cyclosporine/therapeutic use* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use* | - |
dc.subject.MESH | Infliximab/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Salvage Therapy/methods* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Eun Hye Kim | - |
dc.contributor.googleauthor | Duk Hwan Kim | - |
dc.contributor.googleauthor | Soo Jung Park | - |
dc.contributor.googleauthor | Sung Pil Hong | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.identifier.doi | 10.5009/gnl14120 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00377 | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A04404 | - |
dc.contributor.localId | A04030 | - |
dc.contributor.localId | A00827 | - |
dc.contributor.localId | A01539 | - |
dc.relation.journalcode | J00954 | - |
dc.identifier.eissn | 2005-1212 | - |
dc.identifier.pmid | 25473080 | - |
dc.subject.keyword | Colitis, ulcerative | - |
dc.subject.keyword | Cyclosporine | - |
dc.subject.keyword | Infliximab | - |
dc.contributor.alternativeName | Kim, Duk Hwan | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Kim, Eun Hye | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Park, Soo Jung | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.alternativeName | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Kim, Duk Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Kim, Eun Hye | - |
dc.contributor.affiliatedAuthor | Park, Soo Jung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 9 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 601 | - |
dc.citation.endPage | 606 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, Vol.9(5) : 601-606, 2015 | - |
dc.identifier.rimsid | 30514 | - |
dc.type.rims | ART | - |
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