Cited 3 times in
A distinct role for interleukin-6 as a major mediator of cellular adjustment to an altered culture condition
DC Field | Value | Language |
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dc.contributor.author | 김진 | - |
dc.contributor.author | 배정윤 | - |
dc.contributor.author | 배정윤 | - |
dc.date.accessioned | 2016-02-04T11:44:41Z | - |
dc.date.available | 2016-02-04T11:44:41Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0730-2312 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141103 | - |
dc.description.abstract | Tissue microenvironment adjusts biological properties of different cells by modulating signaling pathways and cell to cell interactions. This study showed that epithelial-mesenchymal transition (EMT)/ mesenchymal-epithelial transition (MET) can be modulated by altering culture conditions. HPV E6/E7-transfected immortalized oral keratinocytes (IHOK) cultured in different media displayed reversible EMT/MET accompanied by changes in cell phenotype, proliferation, gene expression at transcriptional, and translational level, and migratory and invasive activities. Cholera toxin, a major supplement to culture medium, was responsible for inducing the morphological and biological changes of IHOK. Cholera toxin per se induced EMT by triggering the secretion of interleukin 6 (IL-6) from IHOK. We found IL-6 to be a central molecule that modulates the reversibility of EMT based not only on the mRNA level but also on the level of secretion. Taken together, our results demonstrate that IL-6, a cytokine whose transcription is activated by alterations in culture conditions, is a key molecule for regulating reversible EMT/MET. This study will contribute to understand one way of cellular adjustment for surviving in unfamiliar conditions. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A distinct role for interleukin-6 as a major mediator of cellular adjustment to an altered culture condition | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학) | - |
dc.contributor.googleauthor | Hwa-Kyung Son | - |
dc.contributor.googleauthor | Iha Park | - |
dc.contributor.googleauthor | Jue Young Kim | - |
dc.contributor.googleauthor | Do Kyeong Kim | - |
dc.contributor.googleauthor | Rasika P. Illeperuma | - |
dc.contributor.googleauthor | Jung Yoon Bae | - |
dc.contributor.googleauthor | Doo Young Lee | - |
dc.contributor.googleauthor | Eun-Sang Oh | - |
dc.contributor.googleauthor | Da-Woon Jung | - |
dc.contributor.googleauthor | Darren R. Williams | - |
dc.contributor.googleauthor | Jin Kim | - |
dc.identifier.doi | 10.1002/jcb.25200 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01009 | - |
dc.relation.journalcode | J01303 | - |
dc.identifier.eissn | 1097-4644 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jcb.25200/abstract | - |
dc.subject.keyword | IL-6 | - |
dc.subject.keyword | CULTURE CONDITION | - |
dc.subject.keyword | EPITHELIAL MESENCHYMAL TRANSITION (EMT) | - |
dc.subject.keyword | MESENCHYMAL EPITHELIAL TRANSITION (MET) | - |
dc.subject.keyword | CHOLERA TOXIN | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.alternativeName | Bae, Jung Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 116 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2552 | - |
dc.citation.endPage | 2562 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR BIOCHEMISTRY, Vol.116(11) : 2552-2562, 2015 | - |
dc.identifier.rimsid | 30513 | - |
dc.type.rims | ART | - |
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