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p62 prevents carbonyl cyanide m-chlorophenyl hydrazine (CCCP)-induced apoptotic cell death by activating Nrf2

DC Field Value Language
dc.contributor.author박정수-
dc.contributor.author배수한-
dc.date.accessioned2016-02-04T11:43:33Z-
dc.date.available2016-02-04T11:43:33Z-
dc.date.issued2015-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141061-
dc.description.abstractCarbonyl cyanide m-chlorophenyl hydrazone (CCCP) is a mitochondrial depolarizing agent that induces reactive oxygen species (ROS)-mediated cell death. The Nrf2-Keap1 pathway is crucial for the elimination of ROS in stressed cells. However, the molecular mechanism underlying the regulation of the Nrf2-Keap1 pathway in CCCP-induced cell death is unknown. In this study, we demonstrated that CCCP promotes Keap1 degradation, and thereby activates Nrf2. This CCCP-mediated Keap1 degradation is partly dependent on autophagy. Moreover, CCCP-induced Keap1 degradation is mainly reliant on p62, which functions as an adaptor protein during selective autophagy. Lack of p62 blocked CCCP-induced Keap1 degradation and inhibited Nrf2 activation, and thereby increased the accumulation of ROS. Ablation of p62 increased the susceptibility of cells to oxidative stress. These results indicate that p62 plays an important role in protecting cells against oxidative stress through Keap1 degradation-mediated Nrf2 activation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1139~1144-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdaptor Proteins, Signal Transducing/metabolism*-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/drug effects-
dc.subject.MESHApoptosis/physiology-
dc.subject.MESHCarbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology*-
dc.subject.MESHCell Line-
dc.subject.MESHFibroblasts/cytology*-
dc.subject.MESHFibroblasts/drug effects-
dc.subject.MESHFibroblasts/metabolism*-
dc.subject.MESHHeat-Shock Proteins/metabolism*-
dc.subject.MESHMice-
dc.subject.MESHNF-E2-Related Factor 2/metabolism*-
dc.subject.MESHOxidative Stress/drug effects-
dc.subject.MESHOxidative Stress/physiology*-
dc.subject.MESHReactive Oxygen Species/metabolism*-
dc.subject.MESHSequestosome-1 Protein-
dc.titlep62 prevents carbonyl cyanide m-chlorophenyl hydrazine (CCCP)-induced apoptotic cell death by activating Nrf2-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorJeong Su Park-
dc.contributor.googleauthorDong Hoon Kang-
dc.contributor.googleauthorSoo Han Bae-
dc.identifier.doi10.1016/j.bbrc.2015.07.093-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01645-
dc.contributor.localIdA01798-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid26208452-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006291X15303235-
dc.subject.keywordAutophagy-
dc.subject.keywordCCCP-
dc.subject.keywordKeap1-
dc.subject.keywordNrf2-
dc.subject.keywordp62-
dc.contributor.alternativeNamePark, Jeong Su-
dc.contributor.alternativeNameBae, Soo Han-
dc.contributor.affiliatedAuthorPark, Jeong Su-
dc.contributor.affiliatedAuthorBae, Soo Han-
dc.rights.accessRightsnot free-
dc.citation.volume464-
dc.citation.number4-
dc.citation.startPage1139-
dc.citation.endPage1144-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.464(4) : 1139-1144, 2015-
dc.identifier.rimsid30488-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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