Cited 25 times in
Unique characteristics and failure patterns of metaplastic breast cancer in contrast to invasive ductal carcinoma: a retrospective multicenter case-control study (KROG 13-07).
DC Field | Value | Language |
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dc.contributor.author | 서창옥 | - |
dc.contributor.author | 김용배 | - |
dc.date.accessioned | 2016-02-04T11:42:45Z | - |
dc.date.available | 2016-02-04T11:42:45Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1526-8209 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141030 | - |
dc.description.abstract | BACKGROUND: This retrospective study was performed to investigate the need for management modification in MBC according to evaluation of characteristics and failure patterns compared with IDC. PATIENTS AND METHODS: We performed this multicenter study taking MBC and randomly assigned IDC cases matched for age (± 3 years), pathologic stage (T and N), locoregional treatment methods (surgery with or without radiation therapy), and period of treatment (± 6 months) that occurred from January 1999 to November 2011 in the 6 institutions of the Korean Radiation Oncology Group. RESULTS: A total of 144 female MBC patients were enrolled. The median follow-up was 51 months (range, 1-186 months). The rates of positivity for estrogen receptor (P < .001), progesterone receptor (P < .001), and HER2 (P = .007) were significantly lower in MBC patients. During follow-up, recurrence developed in 22 (15.3%) MBC and 6 (4.2%) IDC patients (P = .002). The median time to recurrence of MBC and IDC was 15 months and 24 months, respectively. Most instances of recurrence in MBC developed in the triple-negative (TN) subgroup (TN-MBC). In particular, locoregional recurrence developed exclusively in the TN-MBC subgroup. In the TN-MBC subgroup, the number of risk factors (pT2-3, N1-3) was related to significant differences in overall survival (P = .001) and recurrence-free survival (P < .001). CONCLUSION: The MBC patients had a higher rate of TN, poorer differentiation, and a higher recurrence rate than did the IDC patients. Considering the unique characteristics and failure patterns, it is necessary to modify the current management guidelines for MBC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e105~e115 | - |
dc.relation.isPartOf | CLINICAL BREAST CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor/analysis | - |
dc.subject.MESH | Breast Neoplasms/mortality | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/mortality | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/pathology* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Metaplasia | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/mortality* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/mortality | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/pathology* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Unique characteristics and failure patterns of metaplastic breast cancer in contrast to invasive ductal carcinoma: a retrospective multicenter case-control study (KROG 13-07). | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Jeong Il Yu | - |
dc.contributor.googleauthor | Doo Ho Choi | - |
dc.contributor.googleauthor | Seung Jae Huh | - |
dc.contributor.googleauthor | Sung Ja Ahn | - |
dc.contributor.googleauthor | Ji Shin Lee | - |
dc.contributor.googleauthor | Kyung Hwan Shin | - |
dc.contributor.googleauthor | Youngmee Kwon | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.contributor.googleauthor | Jin Hee Kim | - |
dc.contributor.googleauthor | Jihyoung Cho | - |
dc.contributor.googleauthor | In Ah Kim | - |
dc.contributor.googleauthor | Jong Hoon Lee | - |
dc.contributor.googleauthor | Won Park | - |
dc.identifier.doi | 10.1016/j.clbc.2014.10.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A01919 | - |
dc.relation.journalcode | J00562 | - |
dc.identifier.eissn | 1938-0666 | - |
dc.identifier.pmid | 25459069 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1526820914002067 | - |
dc.subject.keyword | Case-control study | - |
dc.subject.keyword | Invasive ductal carcinoma | - |
dc.subject.keyword | Metaplastic breast cancer | - |
dc.subject.keyword | Pattern of failure | - |
dc.subject.keyword | Prognostic factor | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 105 | - |
dc.citation.endPage | 115 | - |
dc.identifier.bibliographicCitation | CLINICAL BREAST CANCER, Vol.15(2) : 105-115, 2015 | - |
dc.identifier.rimsid | 30466 | - |
dc.type.rims | ART | - |
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