Cited 15 times in
Effects of CD4 Monitoring Frequency on Clinical End Points in Clinically Stable HIV-Infected Patients With Viral Suppression
DC Field | Value | Language |
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dc.contributor.author | 안진영 | - |
dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2016-02-04T11:41:46Z | - |
dc.date.available | 2016-02-04T11:41:46Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1525-4135 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140994 | - |
dc.description.abstract | BACKGROUND: Current treatment guidelines for HIV infection recommend routine CD4 lymphocyte (CD4) count monitoring in patients with viral suppression. This may have a limited impact on influencing care as clinically meaningful CD4 decline rarely occurs during viral suppression. METHODS: In a regional HIV observational cohort in the Asia-Pacific region, patients with viral suppression (2 consecutive viral loads <400 copies/mL) and a CD4 count ≥200 cells per microliter who had CD4 testing 6 monthly were analyzed. Main study end points were occurrence of 1 CD4 count <200 cells per microliter (single CD4 <200) and 2 CD4 counts <200 cells per microliter within a 6-month period (confirmed CD4 <200). A comparison of time with single and confirmed CD4 <200 with biannual or annual CD4 assessment was performed by generating a hypothetical group comprising the same patients with annual CD4 testing by removing every second CD4 count. RESULTS: Among 1538 patients, the rate of single CD4 <200 was 3.45/100 patient-years and of confirmed CD4 <200 was 0.77/100 patient-years. During 5 years of viral suppression, patients with baseline CD4 200-249 cells per microliter were significantly more likely to experience confirmed CD4 <200 compared with patients with higher baseline CD4 [hazard ratio, 55.47 (95% confidence interval: 7.36 to 418.20), P < 0.001 versus baseline CD4 ≥500 cells/μL]. Cumulative probabilities of confirmed CD4 <200 was also higher in patients with baseline CD4 200-249 cells per microliter compared with patients with higher baseline CD4. There was no significant difference in time to confirmed CD4 <200 between biannual and annual CD4 measurement (P = 0.336). CONCLUSIONS: Annual CD4 monitoring in virally suppressed HIV patients with a baseline CD4 ≥250 cells per microliter may be sufficient for clinical management. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-HIV Agents/administration & dosage* | - |
dc.subject.MESH | Anti-HIV Agents/pharmacology | - |
dc.subject.MESH | Anti-HIV Agents/therapeutic use | - |
dc.subject.MESH | CD4 Lymphocyte Count* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HIV Infections/drug therapy* | - |
dc.subject.MESH | HIV Infections/immunology | - |
dc.subject.MESH | HIV Infections/virology | - |
dc.subject.MESH | HIV-1/drug effects* | - |
dc.subject.MESH | HIV-1/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.title | Effects of CD4 Monitoring Frequency on Clinical End Points in Clinically Stable HIV-Infected Patients With Viral Suppression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ahn, Jin Young | - |
dc.contributor.googleauthor | Boettiger, David | - |
dc.contributor.googleauthor | Law, Matthew | - |
dc.contributor.googleauthor | Kumarasamy, Nagalingeswaran | - |
dc.contributor.googleauthor | Yunihastuti, Evy | - |
dc.contributor.googleauthor | Chaiwarith, Romanee | - |
dc.contributor.googleauthor | Lee, Man Po | - |
dc.contributor.googleauthor | Sim, Benedict L. H. | - |
dc.contributor.googleauthor | Oka, Shinichi | - |
dc.contributor.googleauthor | Wong, Wingwai | - |
dc.contributor.googleauthor | Kamarulzaman, Adeeba | - |
dc.contributor.googleauthor | Kantipong, Pacharee | - |
dc.contributor.googleauthor | Phanuphak, Praphan | - |
dc.contributor.googleauthor | Ng, Oon Tek | - |
dc.contributor.googleauthor | Kiertiburanakul, Sasisopin | - |
dc.contributor.googleauthor | Zhang, Fujie | - |
dc.contributor.googleauthor | Pujari, Sanjay | - |
dc.contributor.googleauthor | Ditangco, Rossana | - |
dc.contributor.googleauthor | Ratanasuwan, Winai | - |
dc.contributor.googleauthor | Merati, Tuti Parwati | - |
dc.contributor.googleauthor | Saphonn, Vonthanak | - |
dc.contributor.googleauthor | Sohn, Annette H. | - |
dc.contributor.googleauthor | Choi, Jun Yong | - |
dc.identifier.doi | 10.1097/QAI.0000000000000634 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02267 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J01195 | - |
dc.identifier.eissn | 1944-7884 | - |
dc.identifier.pmid | 25850606 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00126334-201507010-00013&LSLINK=80&D=ovft | - |
dc.subject.keyword | HIV infection | - |
dc.subject.keyword | HIV suppression | - |
dc.subject.keyword | CD4 count | - |
dc.subject.keyword | CD4 monitoring | - |
dc.contributor.alternativeName | Ahn, Jin Young | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Jin Young | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 69 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 85 | - |
dc.citation.endPage | 92 | - |
dc.identifier.bibliographicCitation | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol.69(3) : 85-92, 2015 | - |
dc.identifier.rimsid | 30440 | - |
dc.type.rims | ART | - |
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