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Cited 9 times in

Nefopam as an adjunct to intravenous patient-controlled analgesia after renal transplantation: a randomised trial

DC Field Value Language
dc.contributor.author김소연-
dc.contributor.author오영준-
dc.contributor.author최용선-
dc.contributor.author허규하-
dc.date.accessioned2016-02-04T11:41:02Z-
dc.date.available2016-02-04T11:41:02Z-
dc.date.issued2015-
dc.identifier.issn0001-5172-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140967-
dc.description.abstractBACKGROUND: Nefopam has been used as an adjuvant to opioid analgesia after operation. We investigated the efficacy of nefopam as an adjunct to fentanyl-based intravenous patient-controlled analgesia (IV PCA) on post-operative pain relief in patients undergoing renal transplantation. METHODS: Ninety-eight patients undergoing elective renal transplantation were randomised into two groups: nefopam or control groups. The former received nefopam (160 mg in 200 ml at a rate of 4 ml/h) whereas the latter received normal saline during the first 48 h after reperfusion of grafted kidney. Pain intensity scores, cumulative dose of fentanyl, and the incidence of adverse events were assessed at 1, 6, 12, 24, and 48 h post-operatively. Serum creatinine and estimated glomerular filtration rate were evaluated on post-operative days 1, 2, 4, and 7. RESULTS: The cumulative fentanyl consumption during the first 48 h after operation was 19% less in the nefopam group than that in the control group (1005 ± 344 μg vs. 1246 ± 486 μg, mean ± SD; P = 0.006). Pain intensity scores at rest and on coughing were significantly lower in the nefopam group throughout the first 12 and 48 h after operation, respectively. Adverse events and early graft function were comparable between the groups, except a significantly lower incidence of drowsiness observed in the nefopam group (4% vs. 21%, P = 0.027). CONCLUSION: In combination with fentanyl PCA, nefopam reduced post-operative fentanyl consumption with superior analgesia after renal transplantation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1068~1075-
dc.relation.isPartOfACTA ANAESTHESIOLOGICA SCANDINAVICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Intravenous-
dc.subject.MESHAdult-
dc.subject.MESHAnalgesia, Patient-Controlled/methods*-
dc.subject.MESHAnalgesics, Non-Narcotic/administration & dosage-
dc.subject.MESHAnalgesics, Non-Narcotic/therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKidney Transplantation*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNefopam/administration & dosage-
dc.subject.MESHNefopam/therapeutic use*-
dc.subject.MESHPain, Postoperative/drug therapy*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleNefopam as an adjunct to intravenous patient-controlled analgesia after renal transplantation: a randomised trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorS. Y. Kim-
dc.contributor.googleauthorK. H. Huh-
dc.contributor.googleauthorY. H. Roh-
dc.contributor.googleauthorY. J. Oh-
dc.contributor.googleauthorJ. Park-
dc.contributor.googleauthorY. S. Choi-
dc.identifier.doi10.1111/aas.12519-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02389-
dc.contributor.localIdA04119-
dc.contributor.localIdA04344-
dc.contributor.localIdA00616-
dc.relation.journalcodeJ00006-
dc.identifier.eissn1399-6576-
dc.identifier.pmid25903742-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/aas.12519/abstract-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameOh, Young Jun-
dc.contributor.alternativeNameChoi, Yong Seon-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.affiliatedAuthorOh, Young Jun-
dc.contributor.affiliatedAuthorChoi, Yong Seon-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.rights.accessRightsnot free-
dc.citation.volume59-
dc.citation.number8-
dc.citation.startPage1068-
dc.citation.endPage1075-
dc.identifier.bibliographicCitationACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol.59(8) : 1068-1075, 2015-
dc.identifier.rimsid30424-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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