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Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea

Authors
 Sook Hee Chung  ;  Sang Un Park  ;  Jae Hee Cheon  ;  Eun Ran Kim  ;  Jeong-Sik Byeon  ;  Byong Duk Ye  ;  Bora Keum  ;  Ki-Nam Shim  ;  Sung-Ae Jung  ;  Jin-Oh Kim  ;  Seong Ran Jeon  ;  Hyun Joo Song  ;  Jeong Seop Moon  ;  Dong Kyung Chang 
Citation
 Digestive Diseases and Sciences, Vol.60(9) : 2740-2745, 2015 
Journal Title
 Digestive Diseases and Sciences 
ISSN
 0163-2116 
Issue Date
2015
MeSH
Abdominal Pain/etiology ; Adult ; Constriction, Pathologic/etiology ; Constriction, Pathologic/pathology ; Constriction, Pathologic/surgery ; Disease-Free Survival ; Endoscopy, Gastrointestinal ; Enteritis/complications* ; Enteritis/diagnosis ; Enteritis/therapy ; Female ; Humans ; Ileal Diseases/etiology* ; Ileal Diseases/pathology ; Ileal Diseases/therapy ; Jejunal Diseases/etiology* ; Jejunal Diseases/pathology ; Jejunal Diseases/therapy ; Male ; Middle Aged ; Recurrence ; Republic of Korea ; Retrospective Studies ; Ulcer/etiology* ; Ulcer/pathology ; Ulcer/therapy
Keywords
Cryptogenic multifocal ulcerous stenosing enteritis ; Diagnosis ; Characteristics ; Treatment outcome
Abstract
BACKGROUND: Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease that is characterized by multiple, recurring small intestinal ulcers with stenosis of unknown causes. The aim of this study was to investigate the clinical characteristics and the treatment outcomes of patients with CMUSE in Korea. METHODS: We performed a multicenter study to retrospectively analyze clinical data from 20 patients who suffered from CMUSE between 1984 and 2012. Their clinical characteristics and long-term disease courses were investigated. RESULTS: The most common initial symptom of CMUSE was abdominal pain (14/20, 70 %). Small bowel series (13/20, 65 %), double-balloon enteroscopy (12/20, 60 %), CT enterography (12/20, 60 %), and capsule endoscopy (10/20, 50 %) were used to diagnose CMUSE. The strictures of the patients were located in the jejunum (5/20, 25 %), ileum (7/20, 35 %), and both jejunum and ileum (6/20, 30 %). The number of patients in a state of remission, persistent disease, and relapse at the end of follow-up were 13/20 (65 %), 2/20 (10 %), and 5/20 (25 %), respectively. The median relapse-free survival was of 67.1 months. Seventy-five percent relapse-free survivals for female and male patients were 93 and 9 months, respectively (P = 0.031). CONCLUSION: CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.
Full Text
http://link.springer.com/article/10.1007%2Fs10620-015-3595-y
DOI
10.1007/s10620-015-3595-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chung, Sook Hee(정숙희)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140964
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