Cited 16 times in
Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011.
DC Field | Value | Language |
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dc.contributor.author | 김창오 | - |
dc.contributor.author | 홍남기 | - |
dc.date.accessioned | 2016-02-04T11:40:46Z | - |
dc.date.available | 2016-02-04T11:40:46Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0918-8959 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140957 | - |
dc.description.abstract | Although elevated serum gamma-glutamyl transferase activity (GGT) has been linked with metabolic risk factors for sarcopenia, including non-alcoholic fatty liver disease, adiposity, and insulin resistance, whether GGT independently associated with sarcopenia and sarcopenic obesity has not yet been investigated. We analyzed cross-sectional data of 3,193 community-dwelling adults (42.2% men, age 63.4 ± 8.7) aged ≥50 years from the Fifth Korean National Health and Nutrition Examination Survey, 2010-2011. Sarcopenia was defined as a calculated value of the appendicular skeletal muscle mass divided by body weight (ASM/Wt, %) <1 standard deviation below the sex-specific mean for healthy young adults. Sarcopenic obesity was defined as sarcopenia combined with a waist circumference ≥90 cm for men and ≥85 cm for women. The prevalence of sarcopenia and sarcopenic obesity increased stepwise from the lowest to highest GGT quintiles (sarcopenia, 20.2-39.7%; sarcopenic obesity, 7.5-27.3%; P for trend, <0.001). Serum GGT activity was associated negatively with ASM and positively with waist circumference. In multivariate logistic regression analyses, participants in the highest GGT quintile had a 2.3-fold increased risk of sarcopenia and 3.4-fold risk of sarcopenic obesity versus those in the lowest quintile, whereas each single-unit increase in natural log-GGT associated independently with a 35% increased risk of sarcopenia and 62% increased risk of sarcopenic obesity after adjusting for age, sex, body mass index, and other confounders. Elevated serum GGT activity was independently associated with sarcopenia and sarcopenic obesity in community-dwelling older adults. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 585~592 | - |
dc.relation.isPartOf | ENDOCRINE JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Body Composition | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nutrition Surveys | - |
dc.subject.MESH | Obesity/blood* | - |
dc.subject.MESH | Obesity/complications | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Sarcopenia/blood* | - |
dc.subject.MESH | Sarcopenia/complications | - |
dc.subject.MESH | Waist Circumference | - |
dc.subject.MESH | gamma-Glutamyltransferase/blood* | - |
dc.title | Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | Chang Oh Kim | - |
dc.identifier.doi | 10.1507/endocrj.EJ15-0119 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01044 | - |
dc.contributor.localId | A04388 | - |
dc.relation.journalcode | J00769 | - |
dc.identifier.eissn | 1348-4540 | - |
dc.identifier.pmid | 25913781 | - |
dc.subject.keyword | Gamma-glutamyl transferase | - |
dc.subject.keyword | Sarcopenia | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Insulin resistance | - |
dc.contributor.alternativeName | Kim, Chang Oh | - |
dc.contributor.alternativeName | Hong, Nam Ki | - |
dc.contributor.affiliatedAuthor | Kim, Chang Oh | - |
dc.contributor.affiliatedAuthor | Hong, Namki | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 62 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 585 | - |
dc.citation.endPage | 592 | - |
dc.identifier.bibliographicCitation | ENDOCRINE JOURNAL, Vol.62(7) : 585-592, 2015 | - |
dc.identifier.rimsid | 30418 | - |
dc.type.rims | ART | - |
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