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Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011.

DC FieldValueLanguage
dc.contributor.author김창오-
dc.contributor.author홍남기-
dc.date.accessioned2016-02-04T11:40:46Z-
dc.date.available2016-02-04T11:40:46Z-
dc.date.issued2015-
dc.identifier.issn0918-8959-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140957-
dc.description.abstractAlthough elevated serum gamma-glutamyl transferase activity (GGT) has been linked with metabolic risk factors for sarcopenia, including non-alcoholic fatty liver disease, adiposity, and insulin resistance, whether GGT independently associated with sarcopenia and sarcopenic obesity has not yet been investigated. We analyzed cross-sectional data of 3,193 community-dwelling adults (42.2% men, age 63.4 ± 8.7) aged ≥50 years from the Fifth Korean National Health and Nutrition Examination Survey, 2010-2011. Sarcopenia was defined as a calculated value of the appendicular skeletal muscle mass divided by body weight (ASM/Wt, %) <1 standard deviation below the sex-specific mean for healthy young adults. Sarcopenic obesity was defined as sarcopenia combined with a waist circumference ≥90 cm for men and ≥85 cm for women. The prevalence of sarcopenia and sarcopenic obesity increased stepwise from the lowest to highest GGT quintiles (sarcopenia, 20.2-39.7%; sarcopenic obesity, 7.5-27.3%; P for trend, <0.001). Serum GGT activity was associated negatively with ASM and positively with waist circumference. In multivariate logistic regression analyses, participants in the highest GGT quintile had a 2.3-fold increased risk of sarcopenia and 3.4-fold risk of sarcopenic obesity versus those in the lowest quintile, whereas each single-unit increase in natural log-GGT associated independently with a 35% increased risk of sarcopenia and 62% increased risk of sarcopenic obesity after adjusting for age, sex, body mass index, and other confounders. Elevated serum GGT activity was independently associated with sarcopenia and sarcopenic obesity in community-dwelling older adults.-
dc.description.statementOfResponsibilityopen-
dc.format.extent585~592-
dc.relation.isPartOfENDOCRINE JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBody Composition-
dc.subject.MESHBody Mass Index-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHObesity/blood*-
dc.subject.MESHObesity/complications-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSarcopenia/blood*-
dc.subject.MESHSarcopenia/complications-
dc.subject.MESHWaist Circumference-
dc.subject.MESHgamma-Glutamyltransferase/blood*-
dc.titleGamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorEun Young Lee-
dc.contributor.googleauthorChang Oh Kim-
dc.identifier.doi10.1507/endocrj.EJ15-0119-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01044-
dc.contributor.localIdA04388-
dc.relation.journalcodeJ00769-
dc.identifier.eissn1348-4540-
dc.identifier.pmid25913781-
dc.subject.keywordGamma-glutamyl transferase-
dc.subject.keywordSarcopenia-
dc.subject.keywordObesity-
dc.subject.keywordInsulin resistance-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameHong, Nam Ki-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorHong, Namki-
dc.rights.accessRightsfree-
dc.citation.volume62-
dc.citation.number7-
dc.citation.startPage585-
dc.citation.endPage592-
dc.identifier.bibliographicCitationENDOCRINE JOURNAL, Vol.62(7) : 585-592, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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