Cited 132 times in
PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 전경희 | - |
dc.contributor.author | 조한별 | - |
dc.date.accessioned | 2016-02-04T11:40:01Z | - |
dc.date.available | 2016-02-04T11:40:01Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140930 | - |
dc.description.abstract | The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabilization is induced by EGFR- or oncogenic PI3K mutation-mediated AKT activation in cervical cancer. EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase. These processes require the stabilization of MKRN1 via AKT-mediated phosphorylation. In cervical cancer patients with high levels of pAKT and MKRN1 expression, PTEN protein levels are low and correlate with a low 5-year survival rate. Taken together, our results demonstrate that PI3K/AKT signals enforce positive-feedback regulation by suppressing PTEN function. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/genetics | - |
dc.subject.MESH | Adenocarcinoma/metabolism | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Carcinogenesis/genetics | - |
dc.subject.MESH | Carcinoma/genetics* | - |
dc.subject.MESH | Carcinoma/metabolism | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/genetics | - |
dc.subject.MESH | Carcinoma, Squamous Cell/metabolism | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Movement | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia/genetics* | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia/metabolism | - |
dc.subject.MESH | Feedback, Physiological | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | In Vitro Techniques | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Nerve Tissue Proteins/metabolism* | - |
dc.subject.MESH | PTEN Phosphohydrolase/genetics* | - |
dc.subject.MESH | PTEN Phosphohydrolase/metabolism | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases/genetics* | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases/metabolism | - |
dc.subject.MESH | Phosphoproteins | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Protein Processing, Post-Translational | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism* | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/metabolism | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Ribonucleoproteins/metabolism* | - |
dc.subject.MESH | TOR Serine-Threonine Kinases/metabolism | - |
dc.subject.MESH | Ubiquitination | - |
dc.subject.MESH | Uterine Cervical Neoplasms/genetics* | - |
dc.subject.MESH | Uterine Cervical Neoplasms/metabolism | - |
dc.title | PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Min-Sik Lee | - |
dc.contributor.googleauthor | Man-Hyung Jeong | - |
dc.contributor.googleauthor | Hyun-Woo Lee | - |
dc.contributor.googleauthor | Hyun-Ji Han | - |
dc.contributor.googleauthor | Aram Ko | - |
dc.contributor.googleauthor | Stephen M. Hewitt | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.contributor.googleauthor | Kyung-Hee Chun | - |
dc.contributor.googleauthor | Joon-Yong Chung | - |
dc.contributor.googleauthor | Cheolju Lee | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Jaewhan Song | - |
dc.identifier.doi | 10.1038/ncomms8769 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A03501 | - |
dc.contributor.localId | A03921 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 26183061 | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Chun, Kyung Hee | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Chun, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 6 | - |
dc.citation.startPage | 7769 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.6 : 7769, 2015 | - |
dc.identifier.rimsid | 30400 | - |
dc.type.rims | ART | - |
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