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Galactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging

 Dan Heo  ;  Chanjoo Lee  ;  Minhee Ku  ;  Seungjoo Haam  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Sahng Wook Park  ;  Jaemoon Yang 
 NANOTECHNOLOGY, Vol.26(33) : 335101, 2015 
Journal Title
Issue Date
Animals ; Asialoglycoprotein Receptor/metabolism ; Drug Delivery Systems/methods* ; Galactose/chemistry* ; Genetic Vectors/chemistry ; Genetic Vectors/genetics* ; Genetic Vectors/pharmacology ; Genetic Vectors/toxicity ; Hep G2 Cells ; Humans ; Lipid Metabolism/genetics* ; Magnetic Resonance Imaging/methods* ; Magnetite Nanoparticles/chemistry* ; Mice ; Mice, Inbred C57BL ; RNA Interference/drug effects*
magnetic nanovector ; magnetic resonance imaging ; galactosyl ; asialoglycoprotein receptor, RNA interference
The specific delivery of ribonucleic acid (RNA) interfering molecules to disease-related cells is still a critical blockade for in vivo systemic treatment. Here, this study suggests a robust delivery carrier for targeted delivery of RNA-interfering molecules using galactosylated magnetic nanovectors (gMNVs). gMNVs are an organic-inorganic polymeric nanomaterial composed of polycationics and magnetic nanocrystal for delivery of RNA-interfering molecules and tracking via magnetic resonance (MR) imaging. In particular, the surface of gMNVs was modified by galactosylgluconic groups for targeted delivering to asialoglycoprotein receptor (ASGPR) of hepatocytes. Moreover, the small interfering RNAs were used to regulate target proteins related with low-density lipoprotein level and in vivo MR imaging was conducted for tracking of nanovectors. The obtained results show that the prepared gMNVs demonstrate potential as a systemic theragnostic nanoplatform for RNA interference and MR imaging.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
7. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
Yonsei Authors
Ku, Min Hee(구민희) ORCID logo https://orcid.org/0000-0002-1674-1474
Park, Sahng Wook(박상욱) ORCID logo https://orcid.org/0000-0002-9594-7074
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Lee, Chan Joo(이찬주) ORCID logo https://orcid.org/0000-0002-8756-409X
Heo, Dan(허단)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
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