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Galactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging

Authors
 Dan Heo  ;  Chanjoo Lee  ;  Minhee Ku  ;  Seungjoo Haam  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Sahng Wook Park  ;  Jaemoon Yang 
Citation
 Nanotechnology, Vol.26(33) : 335101-335101, 2015 
Journal Title
 Nanotechnology 
ISSN
 0957-4484 
Issue Date
2015
Abstract
The specific delivery of ribonucleic acid (RNA) interfering molecules to disease-related cells is still a critical blockade for in vivo systemic treatment. Here, this study suggests a robust delivery carrier for targeted delivery of RNA-interfering molecules using galactosylated magnetic nanovectors (gMNVs). gMNVs are an organic-inorganic polymeric nanomaterial composed of polycationics and magnetic nanocrystal for delivery of RNA-interfering molecules and tracking via magnetic resonance (MR) imaging. In particular, the surface of gMNVs was modified by galactosylgluconic groups for targeted delivering to asialoglycoprotein receptor (ASGPR) of hepatocytes. Moreover, the small interfering RNAs were used to regulate target proteins related with low-density lipoprotein level and in vivo MR imaging was conducted for tracking of nanovectors. The obtained results show that the prepared gMNVs demonstrate potential as a systemic theragnostic nanoplatform for RNA interference and MR imaging.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140894
DOI
10.1088/0957-4484/26/33/335101
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
구민희(Ku, Min Hee)
박상욱(Park, Sahng Wook)
서진석(Suh, Jin Suck)
양재문(Yang, Jae Moon)
이찬주(Lee, Chan Joo)
허단(Heo, Dan)
허용민(Huh, Yong Min)
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Full Text
http://stacks.iop.org/0957-4484/26/335101
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