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Relationship Between Serum Interleukin-17F Level and Severity of Atopic Dermatitis in Children.

Authors
 Young A Park  ;  Yoon Hee Kim  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim  ;  Kyung Won Kim  ;  Kyung Eun Lee  ;  Mi Na Kim  ;  Jung Yeon Hong  ;  Seo Hee Yoon  ;  In Suk Sol 
Citation
 Allergy Asthma & Respiratory Disease, Vol.28(2), 2015 
Journal Title
 Allergy Asthma & Respiratory Disease 
ISSN
 2151-321X 
Issue Date
2015
Abstract
Background: Recent discovery of the Th17 pathway is providing new opportunities for understanding chronic immune-mediated diseases. The Th17 pathway has been historically associated with chronic inflammatory diseases such as psoriasis, multiple sclerosis, and rheumatoid arthritis. Among Th17 cytokines, pathogenic roles of IL-17A and IL-17F in asthma have been well described. Recently, the number of peripheral blood Th17 cells was found to correlate with disease severity in patients with atopic dermatitis (AD). This study aimed to investigate serum IL-17F levels in children with AD and to correlate this with severity of the disease. Methods: Enzyme-linked immunosorbent assay was used to measure IL-17F levels in the sera of 228 patients with AD and 62 control children. The SCORing Atopic Dermatitis (SCORAD) tool was used to determine the severity of disease. Results: The mean serum level of IL-17F in children with AD was significantly higher than that in the control group (p<0.05) Serum IL-17F levels were also higher in patients with severe AD than in those with mild AD (p<0.001), and IL-17F levels and SCORAD scores were positively correlated (p<0.05). Conclusions: Serum IL-17F level might be a useful marker in children with AD.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140871
Files in This Item:
T201504715.pdf Download
DOI
10.1089/ped.2014.0482
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김규언(Kim, Kyu Earn)
김미나(Kim, Mina) ORCID logo https://orcid.org/0000-0002-1675-0688
김윤희(Kim, Yoon Hee) ORCID logo https://orcid.org/0000-0002-2149-8501
박영아(Park, Young A)
설인숙(Sol, In Suk) ORCID logo https://orcid.org/0000-0003-2470-9682
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
윤서희(Yoon, Seo Hee) ORCID logo https://orcid.org/0000-0002-8361-9815
홍정연(Hong, Jung Yeon)
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