Cited 4 times in
Effect of glucose-insulin-potassium on hyperlactataemia in patients undergoing valvular heart surgery: A randomised controlled study
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심재광 | - |
dc.date.accessioned | 2016-02-04T11:38:11Z | - |
dc.date.available | 2016-02-04T11:38:11Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0265-0215 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140862 | - |
dc.description.abstract | BACKGROUND: Hyperlactataemia represents oxygen imbalance in the tissues and its occurrence during cardiac surgery is associated with adverse outcomes. Glucose-insulin-potassium (GIK) infusion confers myocardial protection against ischaemia-reperfusion injury and has the potential to reduce lactate release while improving its clearance. OBJECTIVES: The objective of this study is to compare the effect of GIK on the incidence of hyperlactataemia in patients undergoing valvular heart surgery. DESIGN: A randomised controlled study. SETTING: Single university teaching hospital. PATIENTS: One hundred and six patients scheduled for elective valvular heart surgery with at least two of the known risk factors for hyperlactataemia. INTERVENTION: Patients were randomly allocated to receive either GIK solution (insulin 0.1 IU kg(-1) h(-1) and an infusion of 30% dextrose and 80 mmol l(-1) potassium at 0.5 ml kg(-1) h(-1)) or 0.9% saline (control) throughout surgery. MAIN OUTCOME MEASURES: The primary outcome was the incidence of hyperlactataemia (lactate ≥ 4 mmol l(-1)) during the operation and until 24 h after the operation. Secondary outcomes included haemodynamic parameters, use of vasopressor or inotropic drugs, and fluid balance until 24 h postoperatively. Postoperative morbidity endpoints were also assessed. RESULTS: The incidences of hyperlactataemia were similar in the groups (32/53 patients in each of the control and GIK groups, P > 0.999). There were no intergroup differences in haemodynamic parameters, use of vasopressor and inotropic drugs, or fluid balance. The incidences of postoperative morbidity endpoints were similar in both groups. CONCLUSION: Despite its theoretical advantage, GIK did not provide beneficial effects in terms of the incidence of hyperlactataemia or outcome in patients undergoing valvular heart surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 555~562 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF ANAESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cardioplegic Solutions/administration & dosage* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucose/administration & dosage | - |
dc.subject.MESH | Heart Valve Prosthesis Implantation/adverse effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperlactatemia/blood | - |
dc.subject.MESH | Hyperlactatemia/diagnosis* | - |
dc.subject.MESH | Hyperlactatemia/prevention & control* | - |
dc.subject.MESH | Infusions, Intravenous | - |
dc.subject.MESH | Insulin/administration & dosage | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Potassium/administration & dosage | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effect of glucose-insulin-potassium on hyperlactataemia in patients undergoing valvular heart surgery: A randomised controlled study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Roh, Go Un | - |
dc.contributor.googleauthor | Shim, Jae Kwang | - |
dc.contributor.googleauthor | Song, Jong Wook | - |
dc.contributor.googleauthor | Kang, Hye Min | - |
dc.contributor.googleauthor | Kwak, Young Lan | - |
dc.identifier.doi | 10.1097/EJA.0000000000000250 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02205 | - |
dc.relation.journalcode | J00807 | - |
dc.identifier.eissn | 1365-2346 | - |
dc.identifier.pmid | 25760680 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003643-201508000-00007&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Song, Jong Wook | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Song, Jong Wook | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 32 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 555 | - |
dc.citation.endPage | 562 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF ANAESTHESIOLOGY, Vol.32(8) : 555-562, 2015 | - |
dc.identifier.rimsid | 30357 | - |
dc.type.rims | ART | - |
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