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Multicenter Analysis of Long-Term Oncologic Impact of Anastomotic Leakage After Laparoscopic Total Mesorectal Excision: The Korean Laparoscopic Colorectal Surgery Study Group
DC Field | Value | Language |
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dc.contributor.author | 백승혁 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 강정현 | - |
dc.contributor.author | 김남규 | - |
dc.date.accessioned | 2016-02-04T11:34:36Z | - |
dc.date.available | 2016-02-04T11:34:36Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140732 | - |
dc.description.abstract | This study aims to validate the oncologic outcomes of anastomotic leakage (AL) after laparoscopic total mesorectal excision (TME) in a large multicenter cohort. The impact of AL after laparoscopic TME for rectal cancer surgery has not yet been clearly described. This was a multicenter retrospective study of 1083 patients who underwent laparoscopic TME for nonmetastatic rectal cancer (stage 0-III). AL was defined as an anastomotic complication within 30 days of surgery irrespective of requiring a reoperation or interventional radiology. Estimated local recurrence (LR), disease-free survival (DFS), and overall survival (OS) were compared between the leakage group and the no leakage group using the log-rank method. Multivariate Cox-regression analysis was used to adjust confounding for survival. The incidence of AL was 6.4%. Mortality within 30 days of surgery occurred in 1 patient (1.4%) in the leakage group and 2 patients (0.2%) in the no leakage group. The leakage group showed a higher LR rate (6.4% vs 1.8%, P = 0.011). Five-year DFS and OS were significantly lower in the leakage group than the no leakage group (DFS 71.7% vs 82.1%, P = 0.016, OS 81.8% vs 93.5%, P = 0.007). Multivariate analysis showed that AL was an independent poor prognostic factor for DFS and OS (hazard ratio [HR] = 1.6; 95% confidence intervals [CI]: 1.0-2.6; P = 0.042, HR = 2.1; 95% CI: 1.0-4.2; P = 0.028, respectively). AL after laparoscopic TME was significantly associated with an increased rate of LR, systemic recurrence and poor OS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anastomotic Leak/etiology* | - |
dc.subject.MESH | Anastomotic Leak/mortality | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant | - |
dc.subject.MESH | Colorectal Surgery/adverse effects* | - |
dc.subject.MESH | Colorectal Surgery/mortality | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Laparoscopy/adverse effects* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Postoperative Complications/epidemiology* | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Rectal Neoplasms/surgery* | - |
dc.subject.MESH | Rectal Neoplasms/therapy | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Multicenter Analysis of Long-Term Oncologic Impact of Anastomotic Leakage After Laparoscopic Total Mesorectal Excision: The Korean Laparoscopic Colorectal Surgery Study Group | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Jeonghyun Kang | - |
dc.contributor.googleauthor | Gyu-Seog Choi | - |
dc.contributor.googleauthor | Jae Hwan Oh | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Jun Seok Park | - |
dc.contributor.googleauthor | Min Jung Kim | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Seung Hyuk Baik | - |
dc.identifier.doi | 10.1097/MD.0000000000001202 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01827 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A00080 | - |
dc.contributor.localId | A00353 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 26200636 | - |
dc.contributor.alternativeName | Baik, Seung Hyuk | - |
dc.contributor.alternativeName | Lee, Kang Young | - |
dc.contributor.alternativeName | Kang, Jeong Hyun | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Baik, Seung Hyuk | - |
dc.contributor.affiliatedAuthor | Lee, Kang Young | - |
dc.contributor.affiliatedAuthor | Kang, Jeong Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 94 | - |
dc.citation.number | 29 | - |
dc.citation.startPage | 1202 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.94(29) : 1202, 2015 | - |
dc.identifier.rimsid | 30274 | - |
dc.type.rims | ART | - |
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