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Vascular endothelial growth factor-expressing neural stem cell for the treatment of neuropathic pain

Authors
 Lee, Hye-Lan ; Oh, Jinsoo ; Ha, Yoon ; Kim, Keung Nyun ; Lee, Minhyung ; Che, Lihua ; You, Youngsang ; Lee, Hye Yeong ; Yun, Yeomin 
Citation
 Neuroreport, Vol.26(7) : 399~404, 2015 
Journal Title
 Neuroreport 
ISSN
 0959-4965 
Issue Date
2015
Abstract
Previously, we determined that vascular endothelial growth factor (VEGF) improves the survival of neural stem cells (NSCs) transplanted into an ischemic environment and effectively enhances angiogenesis. Here, we applied NSCs expressing VEGF (SV-VEGF-NSCs) to treat neuropathic pain. In this study, our goal was to verify the therapeutic effect of SV-VEGF-NSCs by transplanting the cells in a sciatic nerve injury model. We compared the amount of VEGF secreted from DsRed-NSCs (control) or SV-VEGF-NSCs and observed that SV-VEGF-NSCs have a much higher expression level of VEGF. We next investigated whether transplantation with SV-VEGF-NSCs aids functional recovery and pain reduction. We confirmed that transplantation with SV-VEGF-NSCs enhances functional recovery, pain reduction, and remyelination as well as the number of blood vessels compared with the control groups. Our results show that VEGF aids functional recovery and pain reduction in a sciatic nerve injury model.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140697
DOI
10.1097/WNR.0000000000000359
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Neurosurgery
Yonsei Authors
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Link
 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201505010-00003&LSLINK=80&D=ovft
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