Treatment modality of malignant melanoma that metastasized to the mandible and multiple organs: A rare case report and the literature review

Abstract

Malignant melanoma is a neoplasm that arises from melanocytes or melanocytic lesion. It occurs on oral mucosa as a primary lesion or as a metastatic lesion from other organs. It usually metastasizes to the lymph node, lung, and brain. Metastatic melanoma primarily arising from other organs and spreading to the mandible is very rare so its treatment modality is not established yet. Surgery, chemotherapy, radiotherapy, and immunotherapy are applied in various ways but survival rate is still low. General condition of the patient, age, site and number of metastasis, and patient's will to treat must be considered when treating complicated patients.

We report a case of metastatic malignant melanoma which primarily arose from the left great toe and metastasized to mandible and a review of previous reports and recent treatment modalities of metastatic melanoma.