Cited 13 times in
Minimal stimulation using gonadotropin combined with clomiphene citrate or letrozole for intrauterine insemination
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박주현 | - |
dc.contributor.author | 서석교 | - |
dc.contributor.author | 윤보현 | - |
dc.contributor.author | 이병석 | - |
dc.contributor.author | 전승주 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.date.accessioned | 2016-02-04T11:30:23Z | - |
dc.date.available | 2016-02-04T11:30:23Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140577 | - |
dc.description.abstract | PURPOSE: To evaluate the efficacy of minimal stimulation using discretely administered gonadotropin combined with clomiphene citrate (CC) or letrozole (LTZ) for intrauterine insemination (IUI) cycles. MATERIALS AND METHODS: Total 257 IUI cycles from 158 infertile couples were assessed. A CC dose of 100 mg/day (n=126 cycles) or a LTZ dose of 5 mg/day (n=131 cycles) was administered on days 3-5 of the menstrual cycle for 5 days. Each group received human menopausal gonadotropin at a dose of 150 IU by two or three alternative day: CC combined with alternate-day regimen for 2 or 3 days (CC+300, n=37; CC+450, n=89) and LTZ combined with alternate-day regimen for 2 or 3 days (LTZ+300, n=36; LTZ+450, n=95). RESULTS: The clinical pregnancy rate was comparable between the CC and LTZ groups (18.3% vs. 13.0%, p=0.243). The clinical pregnancy rate also showed no significant difference among the 4 groups (21.6% vs. 16.9% vs. 11.1% vs. 12.6%, p=0.507). The multiple pregnancy rate was significantly higher in LTZ compared to CC group (37.5% vs. 8.7%, p=0.028) and in the LTZ+450 compared to CC+450 group (50% vs. 13.3%, p=0.038). Overall, there were 15 cases of ovarian hyperstimulation syndrome (OHSS), with the prevalence being significantly lower in the LTZ compared to CC group (1.5% vs. 10.3%, p=0.003). OHSS was more prevalent in the CC+450 compared to the LTZ+450 group (12.4% vs. 1.1%, p=0.002). CONCLUSION: Our findings suggest that minimal stimulation using two alternate-day gonadotropin with LTZ decreases the development of OHSS and multiple pregnancies, while maintaining comparable pregnancy rates in IUI cycles. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 490~496 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aromatase Inhibitors/administration & dosage | - |
dc.subject.MESH | Clomiphene/administration & dosage* | - |
dc.subject.MESH | Clomiphene/therapeutic use | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fertility Agents, Female/administration & dosage | - |
dc.subject.MESH | Fertility Agents, Female/therapeutic use | - |
dc.subject.MESH | Fertilization in Vitro | - |
dc.subject.MESH | Gonadotropins/administration & dosage* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infertility, Female/drug therapy* | - |
dc.subject.MESH | Insemination, Artificial/statistics & numerical data* | - |
dc.subject.MESH | Nitriles/administration & dosage* | - |
dc.subject.MESH | Ovulation Induction/methods | - |
dc.subject.MESH | Ovulation Induction/statistics & numerical data* | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Pregnancy Rate | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Triazoles/administration & dosage* | - |
dc.title | Minimal stimulation using gonadotropin combined with clomiphene citrate or letrozole for intrauterine insemination | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Bo Hyon Yun | - |
dc.contributor.googleauthor | Seung Joo Chon | - |
dc.contributor.googleauthor | Joo Hyun Park | - |
dc.contributor.googleauthor | Seok Kyo Seo | - |
dc.contributor.googleauthor | SiHyun Cho | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | Seok Hyun Kim | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.identifier.doi | 10.3349/ymj.2015.56.2.490 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01668 | - |
dc.contributor.localId | A01888 | - |
dc.contributor.localId | A02555 | - |
dc.contributor.localId | A02795 | - |
dc.contributor.localId | A03527 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 25684000 | - |
dc.subject.keyword | Intrauterine insemination | - |
dc.subject.keyword | clomiphene citrate | - |
dc.subject.keyword | gonadotropin | - |
dc.subject.keyword | letrozole | - |
dc.subject.keyword | minimal stimulation | - |
dc.contributor.alternativeName | Park, Joo Hyun | - |
dc.contributor.alternativeName | Seo, Seok Kyo | - |
dc.contributor.alternativeName | Yun, Bo Hyon | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.alternativeName | Chon, Seung Joo | - |
dc.contributor.alternativeName | Cho, Si Hyun | - |
dc.contributor.alternativeName | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Park, Joo Hyun | - |
dc.contributor.affiliatedAuthor | Seo, Seok Kyo | - |
dc.contributor.affiliatedAuthor | Yun, Bo Hyon | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Chon, Seung Joo | - |
dc.contributor.affiliatedAuthor | Cho, Si Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Young Sik | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 56 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 490 | - |
dc.citation.endPage | 496 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.56(2) : 490-496, 2015 | - |
dc.identifier.rimsid | 30182 | - |
dc.type.rims | ART | - |
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