Cited 114 times in
Immunogenicity and Safety of a 9-Valent HPV Vaccine
DC Field | Value | Language |
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dc.contributor.author | 김동수 | - |
dc.date.accessioned | 2016-02-04T11:29:43Z | - |
dc.date.available | 2016-02-04T11:29:43Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0031-4005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140551 | - |
dc.description.abstract | OBJECTIVES: Prophylactic vaccination of youngwomen aged 16 to 26 years with the 9-valent (6/11/16/18/31/33/45/52/58) human papillomavirus (HPV) virus-like particle (9vHPV) vaccine prevents infection and disease. We conducted a noninferiority immunogenicity study to bridge the findings in young women to girls and boys aged 9 to 15 years. METHODS: Subjects (N = 3066) received a 3-dose regimen of 9vHPV vaccine administered at day 1, month 2, and month 6. Anti-HPV serologic assays were performed at day 1 and month 7. Noninferiority required that the lower bound of 2-sided 95% confidence intervals of geometric mean titer ratios (boys:young women or girls:young women) be >0.67 for each HPV type. Systemic and injection-site adverse experiences (AEs) and serious AEs were monitored. RESULTS: At 4 weeks after dose 3, >99% of girls, boys, and young women seroconverted for each vaccine HPV type. Increases in geometric mean titers to HPV types 6/11/16/18/31/33/45/52/58 were elicited in all vaccine groups. Responses in girls and boys were noninferior to those of young women. Persistence of anti-HPV responses was demonstrated through 2.5 years after dose 3. Administration of the 9vHPV vaccine was generally well tolerated. A lower proportion of girls (81.9%) and boys (72.8%) than young women (85.4%) reported injection-site AEs, most of which were mild to moderate in intensity. CONCLUSIONS: These data support bridging the efficacy findings with 9vHPV vaccine in young women 16 to 26 years of age to girls and boys 9 to 15 years of age and implementing gender-neutral HPV vaccination programs in preadolescents and adolescents. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e28~e39 | - |
dc.relation.isPartOf | PEDIATRICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alphapapillomavirus/immunology* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Global Health | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Papillomavirus Infections/epidemiology | - |
dc.subject.MESH | Papillomavirus Infections/prevention & control* | - |
dc.subject.MESH | Papillomavirus Infections/virology | - |
dc.subject.MESH | Papillomavirus Vaccines/administration & dosage* | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Vaccination/methods* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Immunogenicity and Safety of a 9-Valent HPV Vaccine | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Pierre Van Damme | - |
dc.contributor.googleauthor | Sven Eric Olsson | - |
dc.contributor.googleauthor | Stanley Block | - |
dc.contributor.googleauthor | Xavier Castellsague | - |
dc.contributor.googleauthor | Glenda E. Gray | - |
dc.contributor.googleauthor | Teobaldo Herrera | - |
dc.contributor.googleauthor | Li-Min Huang | - |
dc.contributor.googleauthor | Dong Soo Kim | - |
dc.contributor.googleauthor | Punnee Pitisuttithum | - |
dc.contributor.googleauthor | Joshua Chen | - |
dc.contributor.googleauthor | Susan Christiano | - |
dc.contributor.googleauthor | Roger Maansson | - |
dc.contributor.googleauthor | Erin Moeller | - |
dc.contributor.googleauthor | Xiao Sun | - |
dc.contributor.googleauthor | Scott Vuocolo | - |
dc.contributor.googleauthor | Alain Luxembourg | - |
dc.identifier.doi | 10.1542/peds.2014-3745 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00405 | - |
dc.relation.journalcode | J02496 | - |
dc.identifier.eissn | 1098-4275 | - |
dc.identifier.pmid | 26101366 | - |
dc.identifier.url | http://pediatrics.aappublications.org/content/136/1/e28.long | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 136 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 28 | - |
dc.citation.endPage | 39 | - |
dc.identifier.bibliographicCitation | PEDIATRICS, Vol.136(1) : 28-39, 2015 | - |
dc.identifier.rimsid | 30166 | - |
dc.type.rims | ART | - |
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