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Serial randomized comparison of strut coverage of everolimus- and first-generation sirolimus-eluting stents

DC FieldValueLanguage
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김정훈-
dc.contributor.author김중선-
dc.contributor.author신동호-
dc.contributor.author장양수-
dc.contributor.author최동훈-
dc.contributor.author홍명기-
dc.date.accessioned2016-02-04T11:27:27Z-
dc.date.available2016-02-04T11:27:27Z-
dc.date.issued2015-
dc.identifier.issn0828-282X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140465-
dc.description.abstractBACKGROUND: There has not been sufficient data to evaluate the serial vascular healing pattern after everolimus-eluting stent (EES) implantation. Using optical coherence tomography, we compared serial changes in strut coverage of the EES and the first-generation sirolimus-eluting stent (SES). METHODS: Sixty patients were randomly assigned to receive either EES (n = 30) or first-generation SES (n = 30) for coronary artery disease. Serial optical coherence tomography evaluation immediately after the procedure, and 3- and 12-month follow-ups were performed in 50 patients with 54 stents (25 patients with 28 EES vs. 25 patients with 26 SES). The percentage of uncovered struts was defined as the ratio of uncovered struts to total struts. The primary end point was the percentage of uncovered struts at 12-month follow-up. The secondary primary end point was the percentage of uncovered struts at the 3-month follow-up and the comparative percentage change (Δ) of uncovered struts at 3- and 12-month follow-ups of EES vs SES. RESULTS: The percentage of uncovered struts was significantly lower in the EES group compared with the SES group (median value, 6.9%; interquartile range [IQR], 3.9-10.6% vs. 11.1%; IQR, 5.5-29.4%, respectively) at the 3-month follow-up (P = 0.03), and at the 12-month follow-up (median value, 1.3%; IQR, 0.3-3.5% vs. 3.6%; IQR, 1.0-9.4%; P = 0.02). The percentage Δ of uncovered struts from the 3- to the 12-month follow-up was similar (-7.0 ± 6.9% in EES vs. -10.5 ± 13.6% in SES; P = 0.24). CONCLUSIONS: The EES group showed more favourable stent strut coverage than the first-generation SES group at the early and late periods after stent implantation. These findings suggest that EES have a more beneficial effect for vascular healing.-
dc.description.statementOfResponsibilityopen-
dc.format.extent723~730-
dc.relation.isPartOfCANADIAN JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAngioplasty, Balloon, Coronary/methods*-
dc.subject.MESHCoronary Angiography/methods-
dc.subject.MESHCoronary Stenosis/diagnostic imaging-
dc.subject.MESHCoronary Stenosis/mortality-
dc.subject.MESHCoronary Stenosis/therapy*-
dc.subject.MESHDrug-Eluting Stents*-
dc.subject.MESHEverolimus-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHProsthesis Design-
dc.subject.MESHRegression Analysis-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSex Factors-
dc.subject.MESHSirolimus/administration & dosage*-
dc.subject.MESHSirolimus/analogs & derivatives*-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleSerial randomized comparison of strut coverage of everolimus- and first-generation sirolimus-eluting stents-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorJeong Hun Kim-
dc.contributor.googleauthorDong-Ho Shin-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.identifier.doi10.1016/j.cjca.2015.01.002-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA02097-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.contributor.localIdA04391-
dc.contributor.localIdA00906-
dc.relation.journalcodeJ00427-
dc.identifier.eissn1916-7075-
dc.identifier.pmid25882337-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0828282X15000240-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Jeong Hun-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorKim, Jeong Hun-
dc.rights.accessRightsnot free-
dc.citation.volume31-
dc.citation.number6-
dc.citation.startPage723-
dc.citation.endPage730-
dc.identifier.bibliographicCitationCANADIAN JOURNAL OF CARDIOLOGY, Vol.31(6) : 723-730, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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