Cited 69 times in
Optical coherence tomographic observation of in-stent neoatherosclerosis in lesions with more than 50% neointimal area stenosis after second-generation drug-eluting stent implantation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍명기 | - |
dc.contributor.author | 고영국 | - |
dc.contributor.author | 김병극 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 신동호 | - |
dc.contributor.author | 이승률 | - |
dc.contributor.author | 이승율 | - |
dc.date.accessioned | 2016-02-04T11:27:25Z | - |
dc.date.available | 2016-02-04T11:27:25Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1941-7640 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140464 | - |
dc.description.abstract | BACKGROUND: Despite the enhanced properties of the second-generation drug-eluting stent (DES), its association with neoatherosclerosis has not been sufficiently evaluated. Therefore, we sought to evaluate and compare neoatherosclerosis in second-generation DESs to first-generation DESs. METHODS AND RESULTS: A total of 212 DES-treated patients with >50% percent neointimal cross-sectional area stenosis were retrospectively enrolled from the Korean multicenter optical coherence tomography (OCT) registry. Within this population, 111 patients had a second-generation DES (40 zotarolimus, 36 everolimus, and 35 biolimus) and 101 patients had a first-generation (65 sirolimus and 36 paclitaxel) DES. Neoatherosclerosis on OCT was defined as neointima formation with the presence of lipids or calcification. OCT-determined neoatherosclerosis was identified in 27.4% (58/212) of all DES-treated lesions. The frequency of neoatherosclerosis increased with the stent age. Stent age was shorter in the second-generation DES group (12.4 months versus 55.4 months, P<0.001), and neoatherosclerosis was less frequently observed in that group (10.8% versus 45.5%, P<0.001). However, after adjusting for cardiovascular risk factors, chronic kidney disease (odds ratio, 4.113; 95% confidence interval, 1.086-15.575; P=0.037), >70 mg/dL of low-density cholesterol at follow-up OCT (odds ratio, 2.532; 95% confidence interval, 1.054-6.084; P=0.038), and stent age (odds ratio, 1.710; 95% confidence interval, 1.403-2.084; P<0.001) were all independent predictors for neoatherosclerosis, whereas the type of DES (first- versus second-generation) was not. Patients with neoatherosclerosis showed a higher rate of acute coronary syndrome at follow-up OCT (19.0% versus 3.9%, respectively, P=0.001). CONCLUSIONS: The second-generation DES is not more protective against neoatherosclerosis compared with the first-generation DES. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Coronary Artery Disease/pathology | - |
dc.subject.MESH | Coronary Artery Disease/therapy* | - |
dc.subject.MESH | Coronary Restenosis/etiology* | - |
dc.subject.MESH | Coronary Restenosis/pathology | - |
dc.subject.MESH | Coronary Restenosis/prevention & control | - |
dc.subject.MESH | Coronary Vessels/pathology* | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neointima* | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Percutaneous Coronary Intervention/adverse effects* | - |
dc.subject.MESH | Percutaneous Coronary Intervention/instrumentation* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prosthesis Design | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tomography, Optical Coherence* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Optical coherence tomographic observation of in-stent neoatherosclerosis in lesions with more than 50% neointimal area stenosis after second-generation drug-eluting stent implantation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Seung-Yul Lee | - |
dc.contributor.googleauthor | Seung-Ho Hur | - |
dc.contributor.googleauthor | Sang-Gon Lee | - |
dc.contributor.googleauthor | Sang-Wook Kim | - |
dc.contributor.googleauthor | Dong-Ho Shin | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.identifier.doi | 10.1161/CIRCINTERVENTIONS.114.001878 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04391 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A02922 | - |
dc.relation.journalcode | J00539 | - |
dc.identifier.eissn | 1941-7632 | - |
dc.identifier.pmid | 25613674 | - |
dc.identifier.url | http://circinterventions.ahajournals.org/content/8/2/e001878.long | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | drug-eluting stent | - |
dc.subject.keyword | optical coherence tomography | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.alternativeName | Lee, Seung Yul | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Seung Yul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 001878 | - |
dc.identifier.bibliographicCitation | CIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol.8(2) : 001878, 2015 | - |
dc.identifier.rimsid | 29918 | - |
dc.type.rims | ART | - |
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