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Optical coherence tomographic observation of in-stent neoatherosclerosis in lesions with more than 50% neointimal area stenosis after second-generation drug-eluting stent implantation

DC FieldValueLanguage
dc.contributor.author장양수-
dc.contributor.author최동훈-
dc.contributor.author홍명기-
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김중선-
dc.contributor.author신동호-
dc.contributor.author이승률-
dc.contributor.author이승율-
dc.date.accessioned2016-02-04T11:27:25Z-
dc.date.available2016-02-04T11:27:25Z-
dc.date.issued2015-
dc.identifier.issn1941-7640-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140464-
dc.description.abstractBACKGROUND: Despite the enhanced properties of the second-generation drug-eluting stent (DES), its association with neoatherosclerosis has not been sufficiently evaluated. Therefore, we sought to evaluate and compare neoatherosclerosis in second-generation DESs to first-generation DESs. METHODS AND RESULTS: A total of 212 DES-treated patients with >50% percent neointimal cross-sectional area stenosis were retrospectively enrolled from the Korean multicenter optical coherence tomography (OCT) registry. Within this population, 111 patients had a second-generation DES (40 zotarolimus, 36 everolimus, and 35 biolimus) and 101 patients had a first-generation (65 sirolimus and 36 paclitaxel) DES. Neoatherosclerosis on OCT was defined as neointima formation with the presence of lipids or calcification. OCT-determined neoatherosclerosis was identified in 27.4% (58/212) of all DES-treated lesions. The frequency of neoatherosclerosis increased with the stent age. Stent age was shorter in the second-generation DES group (12.4 months versus 55.4 months, P<0.001), and neoatherosclerosis was less frequently observed in that group (10.8% versus 45.5%, P<0.001). However, after adjusting for cardiovascular risk factors, chronic kidney disease (odds ratio, 4.113; 95% confidence interval, 1.086-15.575; P=0.037), >70 mg/dL of low-density cholesterol at follow-up OCT (odds ratio, 2.532; 95% confidence interval, 1.054-6.084; P=0.038), and stent age (odds ratio, 1.710; 95% confidence interval, 1.403-2.084; P<0.001) were all independent predictors for neoatherosclerosis, whereas the type of DES (first- versus second-generation) was not. Patients with neoatherosclerosis showed a higher rate of acute coronary syndrome at follow-up OCT (19.0% versus 3.9%, respectively, P=0.001). CONCLUSIONS: The second-generation DES is not more protective against neoatherosclerosis compared with the first-generation DES.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCIRCULATION-CARDIOVASCULAR INTERVENTIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHCoronary Artery Disease/pathology-
dc.subject.MESHCoronary Artery Disease/therapy*-
dc.subject.MESHCoronary Restenosis/etiology*-
dc.subject.MESHCoronary Restenosis/pathology-
dc.subject.MESHCoronary Restenosis/prevention & control-
dc.subject.MESHCoronary Vessels/pathology*-
dc.subject.MESHDrug-Eluting Stents*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeointima*-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPercutaneous Coronary Intervention/adverse effects*-
dc.subject.MESHPercutaneous Coronary Intervention/instrumentation*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProsthesis Design-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTomography, Optical Coherence*-
dc.subject.MESHTreatment Outcome-
dc.titleOptical coherence tomographic observation of in-stent neoatherosclerosis in lesions with more than 50% neointimal area stenosis after second-generation drug-eluting stent implantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSeung-Yul Lee-
dc.contributor.googleauthorSeung-Ho Hur-
dc.contributor.googleauthorSang-Gon Lee-
dc.contributor.googleauthorSang-Wook Kim-
dc.contributor.googleauthorDong-Ho Shin-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.identifier.doi10.1161/CIRCINTERVENTIONS.114.001878-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.contributor.localIdA04391-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA02097-
dc.contributor.localIdA02922-
dc.relation.journalcodeJ00539-
dc.identifier.eissn1941-7632-
dc.identifier.pmid25613674-
dc.identifier.urlhttp://circinterventions.ahajournals.org/content/8/2/e001878.long-
dc.subject.keywordatherosclerosis-
dc.subject.keyworddrug-eluting stent-
dc.subject.keywordoptical coherence tomography-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameLee, Seung Yul-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorLee, Seung Yul-
dc.rights.accessRightsnot free-
dc.citation.volume8-
dc.citation.number2-
dc.citation.startPage001878-
dc.identifier.bibliographicCitationCIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol.8(2) : 001878, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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