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Early gastric cancer with mixed histology predominantly of differentiated type is a distinct subtype with different therapeutic outcomes of endoscopic resection

DC FieldValueLanguage
dc.contributor.author박준철-
dc.contributor.author신성관-
dc.contributor.author심충남-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author이혁-
dc.contributor.author정현수-
dc.date.accessioned2016-02-04T11:25:16Z-
dc.date.available2016-02-04T11:25:16Z-
dc.date.issued2015-
dc.identifier.issn0930-2794-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140386-
dc.description.abstractBACKGROUND: Safety of endoscopic resection (ER) for early gastric cancers (EGC) with mixed histology predominantly of differentiated type has not been securely established, since those lesions tend to exhibit lymph node metastasis, compared to pure differentiated type. The purpose of this study was to evaluate clinicopathologic characteristics, therapeutic outcomes, and risk for lymph node metastasis in predominantly differentiated mixed EGC treated by ER. METHODS: A total of 1,016 patients with 1,039 EGCs underwent ER between January 2007 and June 2013. Enrolled lesions were divided into groups of either pure differentiated (n = 1,011) or predominantly differentiated mixed (n = 28), according to the presence of mixed histology predominantly of differentiated type in ER specimen. RESULTS: Mixed histology predominantly of differentiated type was diagnosed in 2.7% of lesions. Larger size, mid-third location, and moderately differentiated histology on forceps biopsy were independent risk factors for the predominantly differentiated mixed histologic type of EGC in multivariate analysis. En bloc resection rate tended to be lower, and complete and curative resection rates were significantly lower in the predominantly differentiated mixed group. The rate of lymph node metastasis in the lesions with additional operation tended to be higher, in this mixed histology group. CONCLUSIONS: Larger size, mid-third location, and moderately differentiated histology on forceps biopsy carry the significant risk for mixed histology predominantly of differentiated type. EGC with predominantly differentiated mixed histologic type affects therapeutic outcomes and consequent clinical course accompanied by possibly higher risk for lymph node metastasis. The safety of ER for predominantly differentiated mixed EGC should be validated by further prospective investigation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1787~1294-
dc.relation.isPartOfSurgical Endoscopy -
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/diagnosis-
dc.subject.MESHAdenocarcinoma/surgery*-
dc.subject.MESHAged-
dc.subject.MESHBiopsy-
dc.subject.MESHEarly Diagnosis*-
dc.subject.MESHEndoscopy, Gastrointestinal/methods*-
dc.subject.MESHFemale-
dc.subject.MESHGastrectomy/methods*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStomach Neoplasms/diagnosis-
dc.subject.MESHStomach Neoplasms/surgery*-
dc.titleEarly gastric cancer with mixed histology predominantly of differentiated type is a distinct subtype with different therapeutic outcomes of endoscopic resection-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorChoong Nam Shim-
dc.contributor.googleauthorHyunsoo Chung-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorHyuk Lee-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorYong Chan Lee-
dc.identifier.doi10.1007/s00464-014-3861-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01676-
dc.contributor.localIdA02112-
dc.contributor.localIdA02214-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03285-
dc.relation.journalcodeJ02703-
dc.identifier.pmid25277481-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00464-014-3861-7-
dc.subject.keywordEarly gastric cancer-
dc.subject.keywordEndoscopic resection-
dc.subject.keywordHistology-
dc.subject.keywordMixed differentiation-
dc.subject.keywordLymph node metastasis-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameShim, Choong Nam-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLee, Hyuk-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorShim, Choong Nam-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Hyuk-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number7-
dc.citation.startPage1787-
dc.citation.endPage1294-
dc.identifier.bibliographicCitationSurgical Endoscopy , Vol.29(7) : 1787-1294, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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