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Serum 25-hydroxyvitamin D deficiency and increased risk of breast cancer among Korean women: a case-control study

DC Field Value Language
dc.contributor.author류제규-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author박형석-
dc.contributor.author김상화-
dc.contributor.author김승일-
dc.contributor.author김지예-
dc.date.accessioned2016-02-04T11:25:05Z-
dc.date.available2016-02-04T11:25:05Z-
dc.date.issued2015-
dc.identifier.issn0167-6806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140379-
dc.description.abstractDespite the emerging literature supporting the beneficial role of vitamin D on various health outcomes including carcinogenesis, current evidence on the association between vitamin D and breast cancer is still largely inconsistent. Furthermore, this relationship is particularly under explored among Asian population. We conducted a large case-control study with Korean women. We obtained and compared serum 25-hydroxyvitamin D (25(OH)D) between breast cancer patients (N = 3634) and general population (N = 17,133). Moreover, we further examined the association between serum 25(OH)D and breast cancer risk stratified by menopausal status and hormone receptor (HR) status of the tumor. Adjusted odds ratio (OR) for breast cancer comparing women with deficient level of serum 25(OH)D to women with sufficient level of serum 25(OH)D was 1.27 [95 % confidence interval (CI) 1.15-1.39]. This association did not significantly vary by menopausal status [pre-menopause: 1.26 (95 % CI 1.09-1.45) vs. post-menopause: 1.25 (95 % CI 1.10-1.41)]. When stratified by HR status, the inverse association remained significant in both positive and negative statuses. However, this association was more pronounced in HR-negative breast cancer, particularly with triple-negative breast cancer patients (1.45, 95 % CI 1.15-1.82). Given the growing burden of breast cancer in Asia and dearth of studies examining the association between vitamin D and breast cancer risk in Asian women thus far, this study provides a meaningful evidence for potential preventive effect of vitamin D on breast cancer for this particular population.-
dc.description.statementOfResponsibilityopen-
dc.format.extent147~154-
dc.relation.isPartOfBREAST CANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAsian Continental Ancestry Group*-
dc.subject.MESHBreast Neoplasms/epidemiology*-
dc.subject.MESHBreast Neoplasms/etiology*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOdds Ratio-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHVitamin D/analogs & derivatives*-
dc.subject.MESHVitamin D/blood-
dc.subject.MESHVitamin D Deficiency/complications*-
dc.subject.MESHYoung Adult-
dc.titleSerum 25-hydroxyvitamin D deficiency and increased risk of breast cancer among Korean women: a case-control study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorDong Hoon Lee-
dc.contributor.googleauthorJustin Y. Jeon-
dc.contributor.googleauthorJegyu Ryu-
dc.contributor.googleauthorSanghwa Kim-
dc.contributor.googleauthorJee Ye Kim-
dc.contributor.googleauthorHyung Seok Park-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorByeong-Woo Park-
dc.identifier.doi10.1007/s10549-015-3433-0-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01330-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA01753-
dc.contributor.localIdA00533-
dc.contributor.localIdA00658-
dc.contributor.localIdA00984-
dc.relation.journalcodeJ00403-
dc.identifier.eissn1573-7217-
dc.identifier.pmid26037255-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10549-015-3433-0-
dc.subject.keywordVitamin D-
dc.subject.keyword25-Hydroxyvitamin D-
dc.subject.keywordBreast cancer-
dc.subject.keywordMenopausal status-
dc.subject.keywordHormone receptor-
dc.contributor.alternativeNameRyu, Je Gyu-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.alternativeNamePark, Hyung Seok-
dc.contributor.alternativeNameKim, Sang Hwa-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.alternativeNameKim, Jee Ye-
dc.contributor.affiliatedAuthorRyu, Je Gyu-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.contributor.affiliatedAuthorPark, Hyung Seok-
dc.contributor.affiliatedAuthorKim, Sang Hwa-
dc.contributor.affiliatedAuthorKim, Seung Il-
dc.contributor.affiliatedAuthorKim, Jee Ye-
dc.rights.accessRightsnot free-
dc.citation.volume152-
dc.citation.number1-
dc.citation.startPage147-
dc.citation.endPage154-
dc.identifier.bibliographicCitationBREAST CANCER RESEARCH AND TREATMENT, Vol.152(1) : 147-154, 2015-
dc.identifier.rimsid51591-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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