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Glucagon levels, disease severity, and outcome in severe sepsis

DC FieldValueLanguage
dc.contributor.author강영애-
dc.contributor.author김세규-
dc.contributor.author김송이-
dc.contributor.author김영삼-
dc.contributor.author김은영-
dc.contributor.author박무석-
dc.contributor.author박병훈-
dc.contributor.author장준-
dc.contributor.author정경수-
dc.contributor.author정원재-
dc.contributor.author정지예-
dc.date.accessioned2016-02-04T11:24:20Z-
dc.date.available2016-02-04T11:24:20Z-
dc.date.issued2015-
dc.identifier.issn1073-2322-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140351-
dc.description.abstractPURPOSE: Few studies on plasma glucagon levels in patients with sepsis have been performed. We aimed to assess clinical value of glucagon levels in comparison with clinical parameters and severity scores in patients with severe sepsis or septic shock. METHODS: A total of 112 patients who were admitted to intensive care unit with severe sepsis or septic shock were included. Plasma levels of glucagon on days 0, 1, 3, and 7 were serially measured in 112 patients with severe sepsis or septic shock. RESULTS: Compared with survivors, patients who died within 28 days had significantly higher glucagon levels on every day of examination. Glucagon levels were positively correlated with and Acute Physiology and Chronic Health Evaluation II score (day 0, r = 0.288, P < 0.01) and Sequential Organ Failure Assessment (day 0, r = 0.482, P< 0.01; day 1, r = 0.588, P < 0.01; day 3, r = 0.480, P < 0.01; day 7, r = 0.454, P < 0.01). Receiver operating characteristic analysis showed that the area under the curve of glucagon levels to predict 28-day survival was 0.65 (95% confidence interval [CI], 0.55-0.75; P = 0.005), similar to the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores. Multivariate analysis revealed that glucagon levels of greater than 70 pg/mL (hazard ratio, 1.85; 95% CI, 1.03-3.29) and chronic liver disease (hazard ratio, 1.97; 95% CI, 1.02-3.79) were associated with mortality. CONCLUSIONS: Glucagon levels might reflect disease severity and clinical outcomes in patients with severe sepsis or septic shock.-
dc.description.statementOfResponsibilityopen-
dc.format.extent563~568-
dc.relation.isPartOfShock-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers/blood*-
dc.subject.MESHFemale-
dc.subject.MESHGlucagon/blood*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSepsis/blood*-
dc.subject.MESHShock, Septic/blood-
dc.subject.MESHYoung Adult-
dc.titleGlucagon levels, disease severity, and outcome in severe sepsis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung, Won Jai-
dc.contributor.googleauthorPark, Byung Hoon-
dc.contributor.googleauthorChung, Kyung Soo-
dc.contributor.googleauthorKim, Song Yee-
dc.contributor.googleauthorKim, Eun Young-
dc.contributor.googleauthorJung, Ji Ye-
dc.contributor.googleauthorKang, Young Ae-
dc.contributor.googleauthorKim, Young Sam-
dc.contributor.googleauthorKim, Se Kyu-
dc.contributor.googleauthorChang, Joon-
dc.contributor.googleauthorPark, Moo Suk-
dc.identifier.doi10.1097/SHK.0000000000000344-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00057-
dc.contributor.localIdA00602-
dc.contributor.localIdA00626-
dc.contributor.localIdA00707-
dc.contributor.localIdA01457-
dc.contributor.localIdA01478-
dc.contributor.localIdA03472-
dc.contributor.localIdA03570-
dc.contributor.localIdA03677-
dc.contributor.localIdA03735-
dc.contributor.localIdA00811-
dc.relation.journalcodeJ02658-
dc.identifier.pmid25978809-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00024382-201506000-00007&LSLINK=80&D=ovft-
dc.subject.keywordGlucagon-
dc.subject.keywordsepsis-
dc.subject.keywordintensive care unit-
dc.subject.keyworddisease severity-
dc.subject.keywordmortality-
dc.subject.keywordseptic shock-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Song Yi-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameKim, Eun Young-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNamePark, Byung Hoon-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Kyung Soo-
dc.contributor.alternativeNameJung, Won Jai-
dc.contributor.alternativeNameJung, Ji Ye-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.contributor.affiliatedAuthorKim, Song Yi-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorPark, Moo Suk-
dc.contributor.affiliatedAuthorPark, Byung Hoon-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Kyung Soo-
dc.contributor.affiliatedAuthorJung, Won Jai-
dc.contributor.affiliatedAuthorJung, Ji Ye-
dc.contributor.affiliatedAuthorKim, Eun Young-
dc.rights.accessRightsnot free-
dc.citation.volume43-
dc.citation.number6-
dc.citation.startPage563-
dc.citation.endPage568-
dc.identifier.bibliographicCitationShock, Vol.43(6) : 563-568, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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