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Therapy of heavy menstrual bleeding in Korea: Subanalysis and results from a multinational clinical trial in the Asian region investigating the levonorgestrel-releasing intrauterine system versus conventional therapy.
DC Field | Value | Language |
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dc.contributor.author | 이병석 | - |
dc.date.accessioned | 2016-02-04T11:24:18Z | - |
dc.date.available | 2016-02-04T11:24:18Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2287-8572 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140350 | - |
dc.description.abstract | OBJECTIVE: To compare real-life clinical outcomes with the levonorgestrel-releasing intrauterine system (LNG-IUS) and conventional medical therapies (CMTs), including combined oral contraceptives and oral progestins in the treatment of idiopathic heavy menstrual bleeding (HMB) in South Korea. METHODS: This prospective, observational cohort study recruited a total of 647 women aged 18 to 45 years, diagnosed with HMB from 8 countries in Asia, including 209 women from South Korea (LNG-IUS, 169; CMTs, 40), who were followed up to one year. The primary outcome was cumulative continuation rate (still treated with LNG-IUS and CMTs) at 12 months. Secondary outcomes included bleeding pattern, assessment of the treatment efficacy by treating physician and safety profile. RESULTS: The continuation rate at 12 months was significantly higher with the LNG-IUS than CMTs (85.1% vs. 48.5%, respectively; P<0.0001). The 51.5% of CMTs patients discontinued treatment and 18.8% of LNG-IUS patients discontinued treatment. The most common reasons for discontinuation for CMTs were switching to another treatment and personal reasons. When compared to CMTs, the LNG-IUS offered better reduction in subjectively assessed menstrual blood loss and the number of bleeding days, tolerability and with better efficacy in HMB, as assessed by physician's final evaluation. CONCLUSION: This study provides novel information on the real-life treatment patterns of HMB in South Korea. The efficacy of CMTs was inferior compared to the LNG-IUS in the clinical outcomes measured in this study. Due to the better compliance with LNG-IUS, the cumulative continuation rate is higher than CMTs. We conclude that the LNG-IUS should be used as the first-line treatment for HMB in Korean women, in line with international guidelines. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | Obstetrics & Gynecology Science | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Therapy of heavy menstrual bleeding in Korea: Subanalysis and results from a multinational clinical trial in the Asian region investigating the levonorgestrel-releasing intrauterine system versus conventional therapy. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.contributor.googleauthor | Xu Ling | - |
dc.contributor.googleauthor | Shaheena Asif | - |
dc.contributor.googleauthor | Peter Kraemer | - |
dc.contributor.googleauthor | Jens Ulrich Hanisch | - |
dc.contributor.googleauthor | Pirjo Inki | - |
dc.contributor.googleauthor | Jung Eun Lee | - |
dc.identifier.doi | 10.5468/ogs.2015.58.2.162 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02795 | - |
dc.relation.journalcode | J02408 | - |
dc.identifier.pmid | 25798431 | - |
dc.subject.keyword | Compliance | - |
dc.subject.keyword | Heavy menstrual bleeding | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | Levonorgestrel-releasing intrauterine syste | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 58 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 162 | - |
dc.citation.endPage | 170 | - |
dc.identifier.bibliographicCitation | Obstetrics & Gynecology Science, Vol.58(2) : 162-170, 2015 | - |
dc.identifier.rimsid | 51573 | - |
dc.type.rims | ART | - |
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