0 203

Cited 19 times in

Metabolism in embryonic and cancer stemness

Authors
 Hyonchol Jang  ;  Jaemoon Yang  ;  Eugene Lee  ;  Jae-Ho Cheong 
Citation
 ARCHIVES OF PHARMACAL RESEARCH, Vol.38(3) : 381-388, 2015 
Journal Title
 ARCHIVES OF PHARMACAL RESEARCH 
ISSN
 0253-6269 
Issue Date
2015
MeSH
Cell Differentiation/physiology ; Cell Proliferation/physiology ; Embryonic Stem Cells/metabolism* ; Glucose/metabolism ; Glycolysis/physiology ; Humans ; Mitochondria/metabolism ; Neoplasms/metabolism* ; Neoplastic Stem Cells/metabolism* ; Pluripotent Stem Cells/metabolism ; Stress, Physiological/physiology
Keywords
Cancer metabolism ; Stem cell metabolism ; Cancer stem cell metabolism ; O-GlcNAc ; Oxidative phosphorylation ; Cancer stemness
Abstract
Cells constantly adjust their metabolic state in response to extracellular signals and nutrient availability to meet their demand for energy and building blocks. Recently, there has been significant research into the metabolic aspects of embryonic stem cells/pluripotent stem cells (ESCs/PSCs) and cancer stem cells (CSCs), which has revealed the unique metabolic status of different stem cell lineages. While ESCs and CSCs were largely thought to harbor similar metabolic states, recent evidence demonstrates that their metabolic dependency is distinctly different. The glucose metabolism of ESCs largely depends on glycolysis, including a one-carbon pathway during differentiation. While proliferating cancer cells share the glycolytic phenotype of ESCs, the mitochondria-centric oxidative phosphorylation constitutes an important metabolic circuit of CSCs under metabolic stress, indicating the dynamic nature of metabolic plasticity. In this review, we catalogued metabolic signatures of cellular "stemness" to provide insights into the therapeutic potential of ESCs and CSCs.
Full Text
http://link.springer.com/article/10.1007%2Fs12272-015-0558-y
DOI
10.1007/s12272-015-0558-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140332
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse