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[(18)F]FPEB and [(18)F]FDEGPECO comparative study of mGlu5 quantification in rodent brain

Authors
 Jee Hae Kang  ;  Minkyung Lee  ;  Young Hoon Ryu  ;  Chul Hyoung Lyoo  ;  Chul Hoon Kim  ;  Kyo Chul Lee  ;  Tae Hyun Choi  ;  Jae Yong Choi 
Citation
 Applied Radiation and Isotopes, Vol.98 : 103-107, 2015 
Journal Title
 Applied Radiation and Isotopes 
ISSN
 0969-8043 
Issue Date
2015
MeSH
Animals ; Brain/diagnostic imaging* ; Brain/metabolism* ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Fluorine Radioisotopes* ; Hippocampus/diagnostic imaging ; Hippocampus/metabolism ; Male ; Nitriles* ; Oximes* ; Positron-Emission Tomography/methods ; Pyridines* ; Radiopharmaceuticals* ; Rats ; Rats, Sprague-Dawley ; Receptor, Metabotropic Glutamate 5/metabolism* ; Tissue Distribution
Keywords
PET ; [(18)F]FDEGPECO ; [(18)F]FPEB ; mGlu5
Abstract
The aim of this study is to compare [(18)F]FPEB and [(18)F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BPND) values were calculated from the non-invasive Logan's graphical analysis method. Although both radioligands showed similar radiochemical amenability, [(18)F]FPEB PET showed higher brain uptake and superior binding potential values than those of [(18)F]FDEGPECO PET (peak brain uptakes in the hippocampus and the striatum: 7.2-8.7 vs. 5.0-6.2, BPND: 7.3-9.6 vs. 0.3-0.4 for [(18)F]FPEB and [(18)F]FDEGPECO, respectively). In addition, the target-to-reference ratios for [(18)F]FPEB is >4 fold than those of [(18)F]FDEGPECO. From this evidence, we conclude that [(18)F]FPEB is a superior radioligand for mGlu5 imaging in preclinical studies.
Full Text
http://www.sciencedirect.com/science/article/pii/S0969804315000263
DOI
10.1016/j.apradiso.2015.01.025
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140288
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