Cited 37 times in
Repeated neonatal propofol administration induces sex-dependent long-term impairments on spatial and recognition memory in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구본녀 | - |
dc.date.accessioned | 2016-02-04T11:21:19Z | - |
dc.date.available | 2016-02-04T11:21:19Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140240 | - |
dc.description.abstract | Propofol is an anesthetic agent that gained wide use because of its fast induction of anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration and long-term impairment in spatial learning and memory from repeated neonatal propofol administration in animals. Yet, none of those studies has explored the sex-specific long-term physical changes and behavioral alterations such as social (sociability and social preference), emotional (anxiety), and other cognitive functions (spatial working, recognition, and avoidance memory) after neonatal propofol treatment. Seven-day-old Wistar-Kyoto (WKY) rats underwent repeated daily intraperitoneal injections of propofol or normal saline for 7 days. Starting fourth week of age and onwards, rats were subjected to behavior tests including open-field, elevated-plus-maze, Y-maze, 3-chamber social interaction, novel-object-recognition, passive-avoidance, and rotarod. Rats were sacrificed at 9 weeks and hippocampal protein expressions were analyzed by Western blot. Results revealed long-term body weight gain alterations in the growing rats and sex-specific impairments in spatial (female) and recognition (male) learning and memory paradigms. A markedly decreased expression of hippocampal NMDA receptor GluN1 subunit in female- and increased expression of AMPA GluR1 subunit protein expression in male rats were also found. Other aspects of behaviors such as locomotor activity and coordination, anxiety, sociability, social preference and avoidance learning and memory were not generally affected. These results suggest that neonatal repeated propofol administration disrupts normal growth and some aspects of neurodevelopment in rats in a sex-specific manner. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 251~260 | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Repeated neonatal propofol administration induces sex-dependent long-term impairments on spatial and recognition memory in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Edson Luck T. Gonzales | - |
dc.contributor.googleauthor | Sung Min Yang | - |
dc.contributor.googleauthor | Chang Soon Choi | - |
dc.contributor.googleauthor | Darine Froy N. Mabunga | - |
dc.contributor.googleauthor | Hee Jin Kim | - |
dc.contributor.googleauthor | Jae Hoon Cheong | - |
dc.contributor.googleauthor | Jong Hoon Ryu | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.contributor.googleauthor | Chan Young Shin | - |
dc.identifier.doi | 10.4062/biomolther.2014.120 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00193 | - |
dc.relation.journalcode | J00324 | - |
dc.identifier.eissn | 2005-4483 | - |
dc.identifier.pmid | 25995824 | - |
dc.subject.keyword | Anesthesia | - |
dc.subject.keyword | Learning and memory | - |
dc.subject.keyword | Neurodevelopment | - |
dc.subject.keyword | Propofol | - |
dc.subject.keyword | Sex-difference | - |
dc.subject.keyword | Weight gain | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 23 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 251 | - |
dc.citation.endPage | 260 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, Vol.23(3) : 251-260, 2015 | - |
dc.identifier.rimsid | 50372 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.