Cited 53 times in
Comparison of three sedation regimens for drug-induced sleep endoscopy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김은정 | - |
dc.contributor.author | 소사라 | - |
dc.contributor.author | 신서경 | - |
dc.contributor.author | 조진선 | - |
dc.contributor.author | 조형주 | - |
dc.contributor.author | 김혜진 | - |
dc.date.accessioned | 2016-02-04T11:17:49Z | - |
dc.date.available | 2016-02-04T11:17:49Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1520-9512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140109 | - |
dc.description.abstract | PURPOSE: Drug-induced sleep endoscopy (DISE) allows for direct airway observation in patients with obstructive sleep apnea. This study compared the safety profiles and efficacies of three regimens for DISE. METHODS: Sixty-six patients were randomly assigned to receive propofol alone (n = 22), a propofol-remifentanil combination (n = 22), or a dexmedetomidine-remifentanil combination (n = 22). Remifentanil was infused at a concentration of 1.5 ng·ml(-1) in the propofol-remifentanil and dexmedetomidine-remifentanil groups, whereas saline was infused in the propofol group. The propofol and propofol-remifentanil groups received propofol at a starting concentration of 1.0 μg·ml(-1), then 0.1 μg·ml(-1) increments at 5 min intervals. The dexmedetomidine-remifentanil group received 1.0 μg·kg(-1) loading dose of dexmedetomidine for 10 min and then 0.2 μg·kg(-1)·h(-1) increments at 5 min intervals. RESULTS: The incidence of oxygen desaturation was significantly higher in the propofol-remifentanil group compared with that of the dexmedetomidine-remifentanil group (77 vs. 45%, respectively, P = 0.024). Even with a maximum dose of dexmedetomidine (1.4 μg·kg(-1)·h(-1)), 50% of the dexmedetomidine-remifentanil group did not reach sufficient sedation and required additional propofol. Cough reflex occurred in five patients of propofol group and in neither of the other groups (P = 0.004). CONCLUSIONS: The propofol-remifentanil combination was associated with a higher incidence of desaturation. The dexmedetomidine-remifentanil combination was associated with inadequate sedation in one half of the patients, even though it produced less respiratory depression. Addition of remifentanil reduced the cough reflex. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | SLEEP AND BREATHING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Airway Resistance/physiology* | - |
dc.subject.MESH | Conscious Sedation/methods* | - |
dc.subject.MESH | Dexmedetomidine/administration & dosage* | - |
dc.subject.MESH | Dexmedetomidine/adverse effects | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Endoscopy/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxygen/blood | - |
dc.subject.MESH | Piperidines/administration & dosage* | - |
dc.subject.MESH | Piperidines/adverse effects | - |
dc.subject.MESH | Polysomnography/methods* | - |
dc.subject.MESH | Propofol/administration & dosage* | - |
dc.subject.MESH | Propofol/adverse effects | - |
dc.subject.MESH | Sleep Apnea, Obstructive/diagnosis* | - |
dc.subject.MESH | Sleep Apnea, Obstructive/physiopathology* | - |
dc.title | Comparison of three sedation regimens for drug-induced sleep endoscopy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Jin Sun Cho | - |
dc.contributor.googleauthor | Sara Soh | - |
dc.contributor.googleauthor | Eun Jung Kim | - |
dc.contributor.googleauthor | Hyung-ju Cho | - |
dc.contributor.googleauthor | Seokyung Shin | - |
dc.contributor.googleauthor | Hye Jin Kim | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.identifier.doi | 10.1007/s11325-015-1127-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A01960 | - |
dc.contributor.localId | A02109 | - |
dc.contributor.localId | A03914 | - |
dc.contributor.localId | A03936 | - |
dc.contributor.localId | A00816 | - |
dc.relation.journalcode | J02662 | - |
dc.identifier.eissn | 1522-1709 | - |
dc.identifier.pmid | 25643766 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs11325-015-1127-9 | - |
dc.subject.keyword | Obstructive sleep apnea | - |
dc.subject.keyword | Drug-induced sleep endoscopy | - |
dc.subject.keyword | Dexmedetomidine | - |
dc.subject.keyword | Propofol | - |
dc.subject.keyword | Remifentanil | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.alternativeName | Kim, Eun Jung | - |
dc.contributor.alternativeName | Soh, Sa Rah | - |
dc.contributor.alternativeName | Shin, Seo Kyung | - |
dc.contributor.alternativeName | Cho, Jin Sun | - |
dc.contributor.alternativeName | Cho, Hyung Ju | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | Soh, Sa Rah | - |
dc.contributor.affiliatedAuthor | Shin, Seo Kyung | - |
dc.contributor.affiliatedAuthor | Cho, Jin Sun | - |
dc.contributor.affiliatedAuthor | Cho, Hyung Ju | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 711 | - |
dc.citation.endPage | 717 | - |
dc.identifier.bibliographicCitation | SLEEP AND BREATHING, Vol.19(2) : 711-717, 2015 | - |
dc.identifier.rimsid | 53656 | - |
dc.type.rims | ART | - |
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