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Circulating microRNAs as potential biomarkers for endometriosis

DC FieldValueLanguage
dc.contributor.author조시현-
dc.date.accessioned2016-02-04T11:16:36Z-
dc.date.available2016-02-04T11:16:36Z-
dc.date.issued2015-
dc.identifier.issn0015-0282-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140063-
dc.description.abstractOBJECTIVE: To evaluate whether microRNAs (miRNAs) associated with endometriosis are detectable in the circulation and could serve as potential noninvasive biomarkers for endometriosis. DESIGN: Case-control study. SETTING: University hospital. PATIENT(S): Twenty-four women with endometriosis and 24 women without the disease (controls). INTERVENTION(S): Serum samples collected from women undergoing laparoscopy for endometriosis and other benign gynecologic disease. MAIN OUTCOME MEASURE(S): Total RNA extracted from serum and quantitative reverse-transcription polymerase chain reaction to determine levels of miRNA let-7a-f and miR-135a,b. RESULT(S): The levels of circulating let-7b and miR-135a were statistically significantly decreased in women with endometriosis compared with controls, and let-7d and 7f showed a trend toward down-regulation. Let-7b expression strongly correlated with serum CA-125 levels and showed the highest area under the curve of 0.691. When the patients were analyzed according to phase of the menstrual cycle, the expression of let-7b, 7c, 7d, and 7e was statistically significantly lower in the women with endometriosis during the proliferative phase. Using a logistic regression model, we evaluated the diagnostic power of differently expressed miRNAs; the combination of let-7b, let-7d, and let-7f during the proliferative phase yielded the highest area under the curve value of 0.929 in discriminating endometriosis from controls. CONCLUSION(S): Several circulating miRNAs are differentially expressed in the sera of women with endometriosis compared with controls. The combination of serum let-7b, 7d, and 7f levels during the proliferative phase may serve as a diagnostic marker for endometriosis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1252~1260-
dc.relation.isPartOfFERTILITY AND STERILITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHArea Under Curve-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCell Proliferation-
dc.subject.MESHEndometriosis/blood-
dc.subject.MESHEndometriosis/diagnosis*-
dc.subject.MESHEndometriosis/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Markers-
dc.subject.MESHHospitals, University-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMicroRNAs/blood-
dc.subject.MESHMicroRNAs/genetics*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHROC Curve-
dc.subject.MESHReal-Time Polymerase Chain Reaction-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHYoung Adult-
dc.titleCirculating microRNAs as potential biomarkers for endometriosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorSiHyun Cho-
dc.contributor.googleauthorLevent Mutlu-
dc.contributor.googleauthorOlga Grechukhina-
dc.contributor.googleauthorHugh S. Taylor-
dc.identifier.doi10.1016/j.fertnstert.2015.02.013-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03846-
dc.relation.journalcodeJ00894-
dc.identifier.eissn1556-5653-
dc.identifier.pmid25772772-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0015028215001351-
dc.subject.keywordBiomarker-
dc.subject.keywordcirculating miRNAs-
dc.subject.keyworddiagnosis-
dc.subject.keywordendometriosis-
dc.subject.keywordlet-7-
dc.contributor.alternativeNameCho, Si Hyun-
dc.contributor.affiliatedAuthorCho, Si Hyun-
dc.rights.accessRightsnot free-
dc.citation.volume103-
dc.citation.number5-
dc.citation.startPage1252-
dc.citation.endPage1260-
dc.identifier.bibliographicCitationFERTILITY AND STERILITY, Vol.103(5) : 1252-1260, 2015-
dc.identifier.rimsid45606-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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