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Results of ABO-incompatible liver transplantation using a simplified protocol at a single institution

DC Field Value Language
dc.contributor.author이재근-
dc.contributor.author이주한-
dc.contributor.author주동진-
dc.contributor.author주만기-
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.contributor.author김명수-
dc.contributor.author김순일-
dc.date.accessioned2016-02-04T11:16:34Z-
dc.date.available2016-02-04T11:16:34Z-
dc.date.issued2015-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140062-
dc.description.abstractBACKGROUND: Because of the development of various desensitization strategies, ABO-incompatible (ABOi) living donor liver transplantation (LDLT) has become a feasible option for patients with end-stage liver disease. However, there has been no united desensitization protocol for ABOi LDLT. We analyzed the outcomes after establishment of simplified protocol without splenectomy, intravenous immunoglobulin, and local infusion therapy. METHODS: We analyzed 19 ABOi LDLT cases that had been performed between January 2012 and December 2013, without splenectomy and local infusion. We used a single dose of rituximab (375 mg/m(2)) 10 days before transplantation and several series of plasma exchange according to the recipients' iso-agglutinin titer-to-target titer ratio of 1:32. RESULTS: Nineteen recipients received ABOi LTs from living donors. The mean initial immunoglobulin (Ig) M and IgG anti-ABO titers were 76.63 ± 78.81 (range, 8∼256) and 162.53 ± 464.1 (0∼2048). We performed preoperative plasma exchange to 16 recipients (mean number of sessions, 3.58; range, 1-10). After surgery, 9 patients received plasma exchange (mean, 1.84; range 1∼14). One death occurred as the result of pneumonia (5.3%). There were 4 cases of acute rejections (21.1%), and all of them were treated successfully with steroid pulse or thymoglobulin. Antibody-mediated rejection and graft failure did not occur. Six cases of postoperative complications (31.6%) occurred, including 3 cases of infections. There were 2 cases of biliary anastomotic stricture (10.5%) and 1 case of portal vein stenosis (5.3%). CONCLUSIONS: ABOi LDLT with the use of simplified protocol can be safely performed without increased risk of antibody-mediated rejection and other complications.-
dc.description.statementOfResponsibilityopen-
dc.format.extent723~726-
dc.relation.isPartOfTRANSPLANTATION PROCEEDINGS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHABO Blood-Group System/immunology*-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHBlood Group Incompatibility/immunology-
dc.subject.MESHBlood Group Incompatibility/therapy*-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHEnd Stage Liver Disease/immunology-
dc.subject.MESHEnd Stage Liver Disease/surgery*-
dc.subject.MESHFemale-
dc.subject.MESHGraft Rejection/immunology-
dc.subject.MESHGraft Rejection/prevention & control*-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulins, Intravenous/therapeutic use-
dc.subject.MESHImmunosuppressive Agents/therapeutic use-
dc.subject.MESHInfant-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHInfusions, Intravenous-
dc.subject.MESHLiver Transplantation/methods*-
dc.subject.MESHLiving Donors-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlasma Exchange-
dc.subject.MESHRituximab/therapeutic use-
dc.subject.MESHSplenectomy-
dc.subject.MESHTransplantation Conditioning/methods*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleResults of ABO-incompatible liver transplantation using a simplified protocol at a single institution-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJ. Lee-
dc.contributor.googleauthorJ.G. Lee-
dc.contributor.googleauthorJ.J. Lee-
dc.contributor.googleauthorM.S. Kim-
dc.contributor.googleauthorM.K. Ju-
dc.contributor.googleauthorG.H. Choi-
dc.contributor.googleauthorJ.S. Choi-
dc.contributor.googleauthorS.I. Kim-
dc.contributor.googleauthorD.J. Joo-
dc.identifier.doi10.1016/j.transproceed.2015.02.004-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03068-
dc.contributor.localIdA03163-
dc.contributor.localIdA03948-
dc.contributor.localIdA03949-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.contributor.localIdA00649-
dc.contributor.localIdA00424-
dc.relation.journalcodeJ02755-
dc.identifier.eissn1873-2623-
dc.identifier.pmid25891718-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0041134515001177-
dc.contributor.alternativeNameLee, Jae Geun-
dc.contributor.alternativeNameLee, Ju Han-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.alternativeNameJoo, Man Ki-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.affiliatedAuthorLee, Jae Geun-
dc.contributor.affiliatedAuthorLee, Ju Han-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorJoo, Man Ki-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.rights.accessRightsnot free-
dc.citation.volume47-
dc.citation.number3-
dc.citation.startPage723-
dc.citation.endPage726-
dc.identifier.bibliographicCitationTRANSPLANTATION PROCEEDINGS, Vol.47(3) : 723-726, 2015-
dc.identifier.rimsid45605-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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