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Anaplastic lymphoma kinase gene copy number gain in inflammatory breast cancer (IBC): prevalence, clinicopathologic features and prognostic implication

DC FieldValueLanguage
dc.contributor.author김승일-
dc.contributor.author박형석-
dc.contributor.author손주혁-
dc.contributor.author김주항-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author구자승-
dc.contributor.author정준-
dc.date.accessioned2016-02-04T11:16:02Z-
dc.date.available2016-02-04T11:16:02Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140041-
dc.description.abstractBACKGROUND: Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer, and its molecular pathogenesis still remains to be elucidated. This study aimed to evaluate the prevalence and implication of anaplastic lymphoma kinase (ALK) copy number change in IBC patients. METHODS: We retrospectively collected formalin-fixed, paraffin-embedded tumor tissues and medical records of IBC patients from several institutes in Korea. ALK gene copy number change and rearrangement were assessed by fluorescence in situ hybridization (FISH) assay, and ALK expression status was evaluated by immunohistochemical (IHC) staining. RESULTS: Thirty-six IBC patients including those with HER2 (+) breast cancer (16/36, 44.4%) and triple-negative breast cancer (13/36, 36.1%) were enrolled in this study. ALK copy number gain (CNG) was observed in 47.2% (17/36) of patients, including one patient who harbored ALK gene amplification. ALK CNG (+) patients showed significantly worse overall survival compared to ALK CNG (-) patients in univariate analysis (24.9 months vs. 38.1 months, p = 0.033). Recurrence free survival (RFS) after curative mastectomy was also significantly shorter in ALK CNG (+) patients than in ALK CNG (-) patients (n = 22, 12.7 months vs. 43.3 months, p = 0.016). Multivariate Cox regression analysis with adjustment for HER2 and ER statuses showed significantly poorer RFS for ALK CNG (+) patients (HR 5.63, 95% CI 1.11-28.44, p = 0.037). CONCLUSION: This study shows a significant presence of ALK CNG in IBC patients, and ALK CNG was associated with significantly poorer RFS.-
dc.description.statementOfResponsibilityopen-
dc.format.extente0120320-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBreast/pathology*-
dc.subject.MESHFemale-
dc.subject.MESHGene Amplification*-
dc.subject.MESHGene Dosage*-
dc.subject.MESHHumans-
dc.subject.MESHInflammatory Breast Neoplasms/diagnosis-
dc.subject.MESHInflammatory Breast Neoplasms/epidemiology-
dc.subject.MESHInflammatory Breast Neoplasms/genetics*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/analysis-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/genetics*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTriple Negative Breast Neoplasms/diagnosis-
dc.subject.MESHTriple Negative Breast Neoplasms/epidemiology-
dc.subject.MESHTriple Negative Breast Neoplasms/genetics-
dc.titleAnaplastic lymphoma kinase gene copy number gain in inflammatory breast cancer (IBC): prevalence, clinicopathologic features and prognostic implication-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorMin Hwan Kim-
dc.contributor.googleauthorSoohyeon Lee-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorKyung Hae Jung-
dc.contributor.googleauthorIn Hae Park-
dc.contributor.googleauthorJoon Jeong-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorHyung Seok Park-
dc.contributor.googleauthorByeong-Woo Park-
dc.contributor.googleauthorJoo-Hang Kim-
dc.contributor.googleauthorJoohyuk Sohn-
dc.identifier.doi10.1371/journal.pone.0120320-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00658-
dc.contributor.localIdA01753-
dc.contributor.localIdA01995-
dc.contributor.localIdA00945-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA00198-
dc.contributor.localIdA03727-
dc.contributor.localIdA00482-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid25803816-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.alternativeNamePark, Hyung Seok-
dc.contributor.alternativeNameSohn, Joo Hyuk-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameJeong, Joon-
dc.contributor.affiliatedAuthorKim, Seung Il-
dc.contributor.affiliatedAuthorPark, Hyung Seok-
dc.contributor.affiliatedAuthorSohn, Joo Hyuk-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorJeong, Joon-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.number3-
dc.citation.startPagee0120320-
dc.identifier.bibliographicCitationPLOS ONE, Vol.10(3) : e0120320, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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