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Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage.

DC Field Value Language
dc.contributor.author윤호근-
dc.date.accessioned2016-02-04T11:15:48Z-
dc.date.available2016-02-04T11:15:48Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140032-
dc.description.abstractTRAIL can induce apoptosis in some cancer cells and is an immune effector in the surveillance and elimination of developing tumors. Yes, some cancers are resistant to TRAIL. Delphinidin, a polyphenolic compound contained in brightly colored fruits and vegetables, has anti-inflammatory, anti-oxidant, and anti-tumorigenic activities. Here we showed that delphinidin sensitized TRAIL-resistant human prostate cancer cells to undergo apoptosis. Cells treated with delphinidin and TRAIL activated the extrinsic and intrinsic pathways of caspase activation. TRAIL-induced apoptosis in prostate cancer cells pretreated with delphinidin was dependent on death receptor 5 (DR5) and downstream cleavage of histone deacetylase 3 (HDAC3). In conclusion, delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis by inducing DR5, thus causing caspase-mediated HDAC3 cleavage. Our data reveal a potential way of chemoprevention of prostate cancer by enabling TRAIL-mediated apoptosis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent9970~9984-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnthocyanins/administration & dosage-
dc.subject.MESHAnthocyanins/pharmacology*-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/pharmacology*-
dc.subject.MESHApoptosis/drug effects-
dc.subject.MESHCaspases/metabolism-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDrug Synergism-
dc.subject.MESHHistone Deacetylases/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHProstatic Neoplasms/drug therapy*-
dc.subject.MESHProstatic Neoplasms/metabolism-
dc.subject.MESHProstatic Neoplasms/pathology-
dc.subject.MESHReceptors, TNF-Related Apoptosis-Inducing Ligand/biosynthesis*-
dc.subject.MESHReceptors, TNF-Related Apoptosis-Inducing Ligand/metabolism-
dc.subject.MESHTNF-Related Apoptosis-Inducing Ligand/administration & dosage-
dc.subject.MESHTNF-Related Apoptosis-Inducing Ligand/pharmacology*-
dc.subject.MESHTransfection-
dc.titleDelphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorHyeonseok Ko-
dc.contributor.googleauthorMi-Hyeon Jeong-
dc.contributor.googleauthorHyelin Jeon-
dc.contributor.googleauthorGi-Jun Sung-
dc.contributor.googleauthorYoungsin So-
dc.contributor.googleauthorInKi Kim-
dc.contributor.googleauthorJaeKyoung Son-
dc.contributor.googleauthorSang-wook Lee-
dc.contributor.googleauthorHo-Geun Yoon-
dc.contributor.googleauthorKyung-Chul Choi-
dc.identifier.doi10.18632/oncotarget.3667-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02625-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid25991668-
dc.subject.keywordHDAC3-
dc.subject.keywordTRAIL-
dc.subject.keywordapoptosis-
dc.subject.keyworddelphinidin-
dc.subject.keywordprostate cancer-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.rights.accessRightsfree-
dc.citation.volume6-
dc.citation.number12-
dc.citation.startPage9970-
dc.citation.endPage9984-
dc.identifier.bibliographicCitationONCOTARGET , Vol.6(12) : 9970-9984, 2015-
dc.identifier.rimsid45584-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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