Cited 15 times in
Increased Sclerostin Level after Further Ablation of Remnant Estrogen by Aromatase Inhibitors
DC Field | Value | Language |
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dc.contributor.author | 박세희 | - |
dc.contributor.author | 배재현 | - |
dc.contributor.author | 이수진 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 김규리 | - |
dc.contributor.author | 김원진 | - |
dc.contributor.author | 김조은 | - |
dc.contributor.author | 박병우 | - |
dc.date.accessioned | 2016-02-04T11:15:10Z | - |
dc.date.available | 2016-02-04T11:15:10Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140008 | - |
dc.description.abstract | BACKGROUND: Sclerostin is a secreted Wnt inhibitor produced almost exclusively by osteocytes, which inhibits bone formation. Aromatase inhibitors (AIs), which reduce the conversion of steroids to estrogen, are used to treat endocrine-responsive breast cancer. As AIs lower estrogen levels, they increase bone turnover and lower bone mass. We analyzed changes in serum sclerostin levels in Korean women with breast cancer who were treated with an AI. METHODS: We included postmenopausal women with endocrine-responsive breast cancer (n=90; mean age, 57.7 years) treated with an AI, and compared them to healthy premenopausal women (n=36; mean age, 28.0 years). The subjects were randomly assigned to take either 5 mg alendronate with 0.5 μg calcitriol (n=46), or placebo (n=44) for 6 months. RESULTS: Postmenopausal women with breast cancer had significantly higher sclerostin levels compared to those in premenopausal women (27.8±13.6 pmol/L vs. 23.1±4.8 pmol/L, P<0.05). Baseline sclerostin levels positively correlated with either lumbar spine or total hip bone mineral density only in postmenopausal women (r=0.218 and r=0.233; P<0.05, respectively). Serum sclerostin levels increased by 39.9%±10.2% 6 months after AI use in postmenopausal women; however, no difference was observed between the alendronate and placebo groups (39.9%±10.2% vs. 55.9%±9.13%, P>0.05). CONCLUSION: Serum sclerostin levels increased with absolute deficiency of residual estrogens in postmenopausal women with endocrine-responsive breast cancer who underwent AI therapy with concurrent bone loss. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 58~64 | - |
dc.relation.isPartOf | Endocrinology and Metabolism (대한내분비학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Increased Sclerostin Level after Further Ablation of Remnant Estrogen by Aromatase Inhibitors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Wonjin Kim | - |
dc.contributor.googleauthor | Yoonjung Chung | - |
dc.contributor.googleauthor | Se Hwa Kim | - |
dc.contributor.googleauthor | Sehee Park | - |
dc.contributor.googleauthor | Jae Hyun Bae | - |
dc.contributor.googleauthor | Gyuri Kim | - |
dc.contributor.googleauthor | Su Jin Lee | - |
dc.contributor.googleauthor | Jo Eun Kim | - |
dc.contributor.googleauthor | Byeong Woo Park | - |
dc.contributor.googleauthor | Sung Kil Lim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.identifier.doi | 10.3803/EnM.2015.30.1.58 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01525 | - |
dc.contributor.localId | A01803 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A00322 | - |
dc.contributor.localId | A00772 | - |
dc.contributor.localId | A00911 | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A02894 | - |
dc.relation.journalcode | J00773 | - |
dc.identifier.pmid | 25827459 | - |
dc.subject.keyword | Aromatase inhibitors | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | Osteoporosis | - |
dc.subject.keyword | Sclerostin | - |
dc.contributor.alternativeName | Park, Se Hee | - |
dc.contributor.alternativeName | Bae, Jae Hyun | - |
dc.contributor.alternativeName | Lee, Su Jin | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Kim, Gyuri | - |
dc.contributor.alternativeName | Kim, Won Jin | - |
dc.contributor.alternativeName | Kim, Jo Eun | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Park, Se Hee | - |
dc.contributor.affiliatedAuthor | Bae, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Kim, Gyuri | - |
dc.contributor.affiliatedAuthor | Kim, Won Jin | - |
dc.contributor.affiliatedAuthor | Kim, Jo Eun | - |
dc.contributor.affiliatedAuthor | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Lee, Su Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 58 | - |
dc.citation.endPage | 64 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism (대한내분비학회지), Vol.30(1) : 58-64, 2015 | - |
dc.identifier.rimsid | 49023 | - |
dc.type.rims | ART | - |
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