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Self-Doped Conjugated Polymeric Nanoassembly by Simplified Process for Optical Cancer Theragnosis

 Jeonghun Kim  ;  Eugene Lee  ;  Yoochan Hong  ;  Byeonggwan Kim  ;  Minhee Ku  ;  Dan Heo  ;  Jihye Choi  ;  Jongbeom Na  ;  Jungmok You  ;  Seungjoo Haam  ;  Yong-Min Huh  ;  Jin-Suck Suh  ;  Eunkyoung Kim  ;  Jaemoon Yang 
 Advanced Functional Materials, Vol.25(15) : 2260-2269, 2015 
Journal Title
 Advanced Functional Materials 
Issue Date
To access smart optical theragnosis for cancer, an easily processable heterocyclic conjugated polymer (poly(sodium3-((3-methyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepin-3-yl)methoxy)propane-1-sulfonate), PPDS) nanoassembly is fabricated by a surfactant-free one-step process, without the laborious ordinary multicoating process. The conjugated nanoassembly, with a self-doped structure, provides strong absorbance in the near-infrared (NIR) range even in a neutral pH medium and exhibits excellent stability (>six months). In addition, the prepared PPDS nanoassembly shows a high photothermal conversion efficiency of 31.4% in organic photothermal nanoparticles. In particular, the PPDS nanoassembly is stably suspended in the biological medium without any additives. Through a simple immobilization with the anti-CD44 antibody, the prepared biomarker-targetable PPDS nanoassembly demonstrates specific targeting toward CD44 (expressed in stem-like cancer cells), allowing NIR absorbance imaging and the efficient targeted photothermal damaging of CD44-expressing cancer cells, from in vitro 3D mammospheres (similar to the practical structure of tumor in the body) to in vivo xenograft mice tumor models (breast cancer and fibrosarcoma). In this study, the most simplified preparation method is for this organic conjugated polymer-based nanoassembly by a molecular approach is reported, and demonstrated as a highly promising optical nanoagent for optical cancer theragnosis.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
구민희(Ku, Min Hee) ORCID logo https://orcid.org/0000-0002-1674-1474
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
양재문(Yang, Jae Moon) ORCID logo https://orcid.org/0000-0001-7365-0395
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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