309 288

Cited 5 times in

Type I saikosaponins a and d inhibit osteoclastogenesis in bone marrow-derived macrophages and osteolytic activity of metastatic breast cancer cells

Authors
 Ji-Eun Shin  ;  Hyun-Jeong Kim  ;  Ki-Rim Kim  ;  Sun Kyoung Lee  ;  Junhee Park  ;  Hyungkeun Kim  ;  Kwang-Kyun Park  ;  Won-Yoon Chung 
Citation
 Evidence-Based Complementary and Alternative Medicine, Vol.2015 : 582437-582437, 2015 
Journal Title
 Evidence-Based Complementary and Alternative Medicine 
ISSN
 1741-427X 
Issue Date
2015
Abstract
Many osteopenic disorders, including a postmenopausal osteoporosis and lytic bone metastasis in breast and prostate cancers, are linked with a hyperosteoclast activity due to increased receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblastic/stromal cells. Therefore, inhibition of RANKL-induced osteoclastogenesis and osteoclast-induced bone resorption is an important approach in controlling pathophysiology of these skeletal diseases. We found that, of seven type I, II, and III saikosaponins isolated from Bupleurum falcatum, saikosaponins A and D, type I saikosaponins with an allyl oxide linkage between position 13 and 28 and two carbohydrate chains that are directly attached to the hydroxyl groups in position 3, exhibited the most potent inhibition on RANKL-induced osteoclast formation at noncytotoxic concentrations. The stereochemistry of the hydroxyl group at C16 did not affect their activity. Saikosaponins A and D inhibited the formation of resorptive pits by reducing the secreted levels of matrix metalloproteinase- (MMP-) 2, MMP-9, and cathepsin K in RANKL-induced osteoclasts. Additionally, saikosaponins A and D inhibited mRNA expression of parathyroid hormone-related protein as well as cell viability and invasion in metastatic human breast cancer cells. Thus, saikosaponins A and D can serve as a beneficial agent for the prevention and treatment of osteoporosis and cancer-induced bone loss.
Files in This Item:
T201501148.pdf Download
DOI
10.1155/2015/582437
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
김현정(Kim, Hyun-Jeong) ORCID logo https://orcid.org/0000-0003-4608-2120
김형근(Kim, Hyung Keun)
박광균(Park, Kwang Kyun)
박준희(Park, Jun Hee)
박준희(Park, Jun-Hee)
신지은(Shin, Ji Eun)
이선경(Lee, Sun Kyoung) ORCID logo https://orcid.org/0000-0002-3707-8050
정원윤(Chung, Won Yoon) ORCID logo https://orcid.org/0000-0001-8428-9005
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139959
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse