Cited 20 times in
Preconditioning strategies for kidney ischemia reperfusion injury: implications of the "time-window" in remote ischemic preconditioning
DC Field | Value | Language |
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dc.contributor.author | 윤영은 | - |
dc.contributor.author | 이광석 | - |
dc.contributor.author | 최경화 | - |
dc.contributor.author | 한웅규 | - |
dc.contributor.author | 김광현 | - |
dc.contributor.author | 양승철 | - |
dc.date.accessioned | 2016-02-04T11:13:43Z | - |
dc.date.available | 2016-02-04T11:13:43Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139952 | - |
dc.description.abstract | Remote ischemic preconditioning (IP) is a potential renoprotective strategy. However, there has been no demonstrated result in large animals and the role of time window in remote IP remains to be defined. Using a single-kidney porcine model, we evaluated organ protective function of remote IP in renal ischemia reperfusion injury. Fifteen Yorkshire pigs, 20 weeks old and weighing 35-38 kg were used. One week after left nephrectomy, we performed remote IP (clamping right external iliac artery, 2 cycles of 10 minutes) and right renal artery clamping (warm ischemia; 90 minutes). The animals were randomly divided into three groups: control group, warm ischemia without IP; group 1 (remote IP with early window [IP-E]), IP followed by warm ischemia with a 10-minute time window; and group 2 (remote IP with late window [IP-L]), IP followed by warm ischemia after a 24-hour time window. There were no differences in serum creatinine changes between groups. The IP-L group had lower urinary neutrophil gelatinase-associated lipocalin than control and IP-E at 72 hours post-ischemia. At 72 hours post-ischemia, the urinary kidney injury molecule-1 (KIM-1) was lower in the IP-L group than in the control and IP-E groups, and the IP-L group KIM-1 was near pre-ischemic levels, whereas the control and IP-E group KIM-1 levels were rising. Microalbumin also tended to be lower in the IP-L group. Taken together, remote IP showed a significant reduction in renal injury biomarkers from ischemia reperfusion injury. To effectively provide kidney protection, remote IP might require a considerable, rather than short, time window of ischemia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomarkers/urine | - |
dc.subject.MESH | Creatinine/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Ischemic Preconditioning* | - |
dc.subject.MESH | Kidney/blood supply* | - |
dc.subject.MESH | Reperfusion Injury/prevention & control* | - |
dc.subject.MESH | Swine | - |
dc.title | Preconditioning strategies for kidney ischemia reperfusion injury: implications of the "time-window" in remote ischemic preconditioning | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Young Eun Yoon | - |
dc.contributor.googleauthor | Kwang Suk Lee | - |
dc.contributor.googleauthor | Kyung Hwa Choi | - |
dc.contributor.googleauthor | Kwang Hyun Kim | - |
dc.contributor.googleauthor | Seung Choul Yang | - |
dc.contributor.googleauthor | Woong Kyu Han | - |
dc.identifier.doi | 10.1371/journal.pone.0124130 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02581 | - |
dc.contributor.localId | A02668 | - |
dc.contributor.localId | A04036 | - |
dc.contributor.localId | A04308 | - |
dc.contributor.localId | A02294 | - |
dc.contributor.localId | A00319 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 25879855 | - |
dc.contributor.alternativeName | Yoon, Young Eun | - |
dc.contributor.alternativeName | Lee, Kwang Suk | - |
dc.contributor.alternativeName | Choi, Kyung Hwa | - |
dc.contributor.alternativeName | Han, Woong Kyu | - |
dc.contributor.alternativeName | Kim, Kwang Hyun | - |
dc.contributor.alternativeName | Yang, Seung Choul | - |
dc.contributor.affiliatedAuthor | Yoon, Young Eun | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Suk | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Hwa | - |
dc.contributor.affiliatedAuthor | Han, Woong Kyu | - |
dc.contributor.affiliatedAuthor | Yang, Seung Choul | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Hyun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e0124130 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.10(4) : e0124130, 2015 | - |
dc.identifier.rimsid | 48402 | - |
dc.type.rims | ART | - |
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